ZOSYN 3.375g Rx
Generic Name and Formulations:
Piperacillin 3g, tazobactam 0.375g; IV; sodium content 2.84mEq/g of piperacillin.
Company:
Pfizer Inc.

Select therapeutic use:
Indications for ZOSYN 3.375g:
Susceptible intra-abdominal infections (eg, appendicitis, peritonitis), skin and skin structure, moderate community-acquired pneumonia, moderate to severe nosocomial pneumonia, postpartum endometritis, pelvic inflammatory disease.

Adult:
Infuse over 30 mins. Usually 3.375g every 6hrs for 7–10 days; renal impairment (CrCl 20–40mL/min): 2.25g every 6hrs; CrCl <20mL/min: 2.25g every 8hrs; hemodialysis or peritoneal dialysis: 2.25g every 12hrs, give additional 0.75g at end of hemodialysis. Nosocomial pneumonia: 4.5g every 6hrs for 7–14 days (give with an aminoglycoside for P. aeruginosa); renal impairment (CrCl 20–40mL/min): 3.375g every 6hrs; CrCl <20mL/min: 2.25g every 6hrs; hemodialysis or peritoneal dialysis: 2.25g every 8hrs, give additional 0.75g at end of hemodialysis.

Children:
<2 months: not established. Infuse over 30 mins. Appendicitis/peritonitis: 2 months–9 months: 80mg/10mg per kg every 8hrs. ≥9 months: (≤40kg): 100mg/12.5mg per kg every 8hrs; (>40kg): use Adult dose. Renal impairment: not determined.

Contraindications:
Penicillin, cephalosporin, or β-lactamase inhibitor allergy.

Warnings/Precautions:
Discontinue if hypersensitivity occurs or severe skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS) progress; monitor closely. Renal dysfunction. Higher doses increase seizure risk. Cystic fibrosis (increased fever/rash risk). Monitor electrolytes, hematopoiesis; discontinue if bleeding disorders occur. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:
Potentiated by probenecid. May antagonize aminoglycosides (eg, tobramycin); monitor. May potentiate non-depolarizing muscle relaxants (eg, vecuronium). Monitor methotrexate, heparin, anticoagulants. Monitor renal function with concomitant vancomycin. May cause false (+) Clinitest, Coomb's or Bio-Rad Aspergillus EIA test.

See Also:
ZOSYN 2.25g

ZOSYN 4.5g

Pharmacological Class:
Broad-spectrum penicillin + β-lactamase inhibitor.

Adverse Reactions:
Diarrhea, constipation, nausea, headache, insomnia; rash (may be severe), pruritus, local reactions, C. difficile-associated diarrhea; rare: bleeding.

How Supplied:
Single-dose vials—10