ZINACEF(cefuroxime for injection)
Zinacef Drug Information
cefuroxime - Drug Summary
CLASSES
2nd Generation Cephalosporin and Cephamycin Antibiotics
DEA CLASS
Rx
DESCRIPTION
Oral/parenteral second-generation cephalosporin. Common clinical uses include severe upper and lower respiratory tract infections, skin infections, otitis media, and surgical prophylaxis.
COMMON BRAND NAMES
Alti-Cefuroxime, Ceftin, Kefurox, Zinacef
HOW SUPPLIED
Alti-Cefuroxime/Ceftin/Cefuroxime/Cefuroxime Axetil Oral Tab: 250mg, 500mg
Ceftin/Cefuroxime/Cefuroxime Axetil Oral Pwd F/Recon: 5mL, 125mg, 250mg
Cefuroxime/Cefuroxime Sodium/Kefurox/Zinacef Intramuscular Inj Pwd F/Sol: 1.5g, 7.5g, 750mg
Cefuroxime/Cefuroxime Sodium/Kefurox/Zinacef Intravenous Inj Pwd F/Sol: 1.5g, 7.5g, 750mg
Zinacef Intravenous Inj Sol: 1mL, 15mg, 30mg
DOSAGE & INDICATIONS
For the treatment of mild-to-moderate acute bacterial exacerbations of chronic bronchitis.
Oral dosage (tablets)
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Adults
250 to 500 mg PO every 12 hours for 10 days.
Adolescents
250 to 500 mg PO every 12 hours for 10 days.
For the treatment of skin and skin structure infections.
For mild to moderate uncomplicated skin and skin structure infections.
Oral dosage (tablets)
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Adults and Adolescents
250 mg to 500 mg PO every 12 hours for 10 days.
Intravenous dosage
Adults
750 mg IV every 8 hours.
Infants 3 months and older, Children, and Adolescents
50 to 100 mg/kg/day IV in equally divided doses every 6 to 8 hours (Max: 2.25 g/day).
Intramuscular dosage
Adults
750 mg IM every 8 hours.
Infants 3 months and older, Children, and Adolescents
50 to 100 mg/kg/day IM in equally divided doses every 6 to 8 hours (Max: 2.25 g/day).
For serious skin and skin structure infections.
Intravenous dosage
Adults
1.5 g IV every 8 hours. For life-threatening infections or infections due to less susceptible organisms, 1.5 g IV every 6 hours may be required.
Infants 3 months and older, Children, and Adolescents
100 mg/kg/day IV in equally divided doses every 6 to 8 hours (Max: 6 g/ day).
Intramuscular dosage
Infants 3 months and older, Children, and Adolescents
100 mg/kg/day IM in equally divided doses every 6 to 8 hours (Max: 6 g/ day).
For the treatment of impetigo.
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Oral dosage (suspension)
Infants 3 months and older and Children
30 mg/kg/day PO divided into 2 doses (Max: 1000 mg/day).
For the treatment of urinary tract infection (UTI).
Oral dosage (tablet)
Adults and Adolescents
250 mg PO every 12 hours for 7 to 10 days. The Infectious Diseases Society of America (IDSA) recommends beta-lactams used for 3 to 7 days as alternative therapy for cystitis when other agents cannot be used. For pyelonephritis, oral beta-lactams should be used after an initial intravenous dose of a long-acting antimicrobial (ceftriaxone or aminoglycoside) for 10 to 14 days. Beta-lactams generally have inferior efficacy than other agents.
Intravenous dosage
Adults
0.75 to 1.5 g IV every 8 hours in general or 0.75 g IV every 8 hours for uncomplicated UTIs.
Infants 3 months and older, Children, and Adolescents |
