RENAGEL TABLETS
Generic Name and Formulations:
Sevelamer HCl 400mg, 800mg.

Company:
Genzyme Corporation
Indications for RENAGEL TABLETS:
Reduction of serum phosphorus in end stage renal disease in patients on hemodialysis.

Adult Dose for RENAGEL TABLETS:
Swallow whole with meals. Patients not taking a phosphate binder: serum phosphorus >5.5 to <7.5mg/dL: 800mg 3 times daily; 7.5–9mg/dL: 1.2–1.6g 3 times daily; ≥9mg/dL: 1.6g 3 times daily. Titrate by 1 tab per meal at 2-week intervals to keep serum phosphorus ≤5.5mg/dL. Switching from calcium acetate to sevelamer: see literature.

Children's Dose for RENAGEL TABLETS:
Not recommended.

Pharmacological Class:
Phosphate binder.

Contraindications:
Hypophosphatemia. Bowel obstruction.

Warnings/Precautions:
Dysphagia. Swallowing disorders. Severe GI motility disorders. Major GI tract surgery. Monitor serum calcium, bicarbonate, chloride. Pregnancy (Cat.C).

Interactions:
Separate narrow therapeutic index drugs by 1 hr before or 3 hrs after sevelamer, or monitor.

Adverse Reactions:
GI upset, headache, constipation.

How Supplied:
Tabs 400mg—360; 800mg—180