EMEND(aprepitant for oral suspension)阿瑞吡坦混悬液
Generic Name and Formulations:
Aprepitant 125mg; per pouch; pwd for oral susp after reconstitution.
Company:
Merck & Co., Inc.

Select therapeutic use: Nausea
Indications for EMEND for ORAL SUSPENSION:
In combination with other antiemetic agents, in patients ≥6mos of age for prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately to highly emetogenic cancer chemotherapy, including high-dose cisplatin.

Adults and Children:
<6mos or <6kg: not recommended. Give with corticosteroid and 5-HT3 antagonist (see full labeling). 6mos–<12yrs or patients (Peds or Adults) unable to swallow: 3mg/kg (max 125mg) on Day 1; then 2mg/kg (max 80mg) on Days 2 and 3. Administer susp 1hr prior to chemotherapy on Days 1, 2, and 3; if no chemotherapy is given on Days 2 and 3, administer susp in the AM.

Contraindications:
Concomitant pimozide.

Warnings/Precautions:
Not for chronic continuous use. Severe hepatic impairment. Pregnancy. Nursing mothers.

Interactions:
See Contraindications. Monitor, and caution with, CYP3A4 substrates, including chemotherapy agents (eg, ifosfamide, vinblastine, vincristine). Avoid concomitant moderate-to-strong CYP3A4 inhibitors (eg, azole antifungals, macrolides, nefazodone, ritonavir, nelfinavir, diltiazem) or strong CYP3A4 inducers (eg, carbamazepine, phenytoin, rifampin). Potentiates dexamethasone (reduce its dose by 50%), methylprednisolone (reduce its IV dose by 25% and its oral dose by 50%), midazolam, alprazolam, triazolam. May antagonize warfarin (closely monitor INR for 2 weeks after starting each regimen), other CYP2C9 substrates, oral contraceptives (use alternative or backup method during and for 1 month after last dose).

See Also:
EMEND

EMEND INJECTION

Pharmacological Class:
Substance P/NK1 receptor antagonist.

Adverse Reactions:
Fatigue, diarrhea, asthenia, dyspepsia, abdominal pain, hiccups, WBC count decreased, dehydration, ALT/AST increased, neutropenia, headache, anorexia, cough, hemoglobin decreased, dizziness, constipation, hypotension. Injection: inj site pain.

Generic Availability:
NO

How Supplied:
Caps 40mg—1, 5; 80mg, 125mg—6; Bi-fold pack (2 x 80mg)—1; Tri-fold pack (1 x 125mg + 2 x 80mg)—1; Susp kit—1 (w. oral dispensers, supplies); Vial—1