DILANTIN SUSPENSION Rx
Generic Name and Formulations:
Phenytoin 125mg/5mL; max alcohol 0.6%.
Company:
Pfizer Inc.
Tonic-clonic, psychomotor and neurosurgically induced seizures.

Adult:
1 teaspoonful 3 times daily; may increase to 5 teaspoonfuls daily if necessary.

Children:
Initially 5mg/kg per day in 2–3 equally divided doses. Increase weekly if needed. Usual maintenance: 4–8mg/kg per day; max 300mg daily.

Contraindications:
Concomitant delavirdine.

Warnings/Precautions:
Suicidal tendencies (monitor). Diabetes. Impaired liver function. Discontinue if acute hepatotoxicity occurs; do not restart. Adjust dose gradually. Discontinue if first sign of rash develops. Monitor serum levels when switching between sodium salt of phenytoin (caps) and free acid form (suspension, Infatabs). Use proper dental hygiene. Hormonal contraception. Monitor bone mineral density with chronic use. Porphyria. Elderly. Debilitated. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:
Potentiated by acute alcohol ingestion, amiodarone, antiepileptic agents (eg, ethosuximide, felbamate, oxcarbazepine, methsuximide, topiramate), azoles (eg, fluconazole, ketoconazole, itraconazole, miconazole, voriconazole), benzodiazepines (eg, chlordiazepoxide, diazepam), capecitabine, chloramphenicol, disulfiram, estrogens, fluorouracil, fluoxetine, fluvastatin, fluvoxamine, halothane, H2-blockers (eg, cimetidine), isoniazid, methylphenidate, omeprazole, phenothiazines, salicylates, sertraline, succinamides (eg, ethosuximide), sulfonamides, ticlopidine, tolbutamide, trazodone, warfarin. Antagonized by anticancer drugs (eg, bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate), chronic alcohol ingestion, carbamazepine, diazepam, folic acid, fosamprenavir, nelfinavir, reserpine, rifampin, ritonavir, St. John’s wort, sucralfate, theophylline, vigabatrin. Antagonizes albendazole, HIV antivirals (eg, efavirenz, lopinavir/ritonavir, indinavir, nelfinavir, ritonavir, saquinavir), antiepileptic agents (eg, carbamazepine, felbamate, lamotrigine, topiramate, oxcarbazepine, quetiapine), atorvastatin, fluvastatin, simvastatin, chlorpropamide, clozapine, cyclosporine, digoxin, folic acid, methadone, mexiletine, nifedipine, nimodipine, nisoldipine, praziquantel, verapamil. Reduces efficacy of concomitant azoles, corticosteroids, doxycycline, estrogens, furosemide, irinotecan, oral contraceptives, paclitaxel, paroxetine, quinidine, rifampin, sertraline, teniposide, theophylline, vitamin D, warfarin. Concomitant fosamprenavir/ritonavir may potentiate amprenavir. Concomitant neuromuscular blockers (eg, pancuronium, vecuronium, rocuronium, cisatracurium); may need higher infusion rate. Variable effects with phenobarbital, valproic acid, sodium valproate. Absorption decreased by calcium, antacids.

See Also:
DILANTIN

DILANTIN INFATABS

Pharmacological Class:
Hydantoin.

Adverse Reactions:
Nystagmus, ataxia, slurred speech, decreased coordination, somnolence, mental confusion, headaches, dizziness, cerebellar atrophy, nausea, vomiting, constipation, gingival hyperplasia, osteomalacia, blood dyscrasias, lymphadenopathy, hepatic disease, hyperglycemia, SLE, hypertrichosis; rare: rash (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), DRESS, multiorgan hypersensitivity.

Note:
To enroll in the North American Antiepileptic Drug Pregnancy Registry call (888) 233-2334.

Generic Availability:
YES

How Supplied:
Caps 30mg—100; 100mg—100, 1000; Tabs—100; Susp—8oz