COZAAR Rx
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COZAAR
Diabetes 
Hypertension  Only 4 drugs may be compared at once

Generic Name and Formulations:
Losartan potassium 25mg, 50mg, 100mg; tabs.
Company:
Merck & Co., Inc.
 
Select therapeutic use: Diabetes
Hypertension
Indications for COZAAR:
Treatment of diabetic nephropathy in type 2 diabetes with hypertension.

Adult:
Initially 50mg once daily; may increase to 100mg once daily.

Children:
Not established.

Contraindications:
Concomitant aliskiren in patients with diabetes.

Warnings/Precautions:
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before starting therapy, or reduce initial dose. Renal impairment: monitor for worsening renal function. Hepatic impairment; reduce dose. Severe CHF. Renal artery stenosis. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:
See Contraindications. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. Potentiated by fluconazole. Antagonized by rifampin. May be antagonized by, and renal toxicity potentiated by NSAIDs, including selective COX-2 inhibitors (monitor renal function periodically in elderly and/or volume-depleted). Monitor lithium. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Avoid concomitant aliskiren in renal impairment (CrCl <60mL/min).

Pharmacological Class:
Angiotensin II receptor blocker (ARB).

Adverse Reactions:
Upper respiratory tract infection, dizziness, insomnia, muscle cramps, leg pain, hyperkalemia, angioedema, orthostatic hypotension, rhabdomyolysis (rare).

Metabolism:
Hepatic (CYP2C9, 3A4).

Elimination:
Fecal, renal.

Generic Availability:
YES

How Supplied:
Tabs 25mg—90, 1000; 50mg, 100mg—30, 90, 1000