REPATHA Rx
Add Drug To My List Compare to related Drugs View/edit/Compare drugs in my list
Select the drug indication to add to your list
REPATHA
Hyperlipoproteinemias  Only 4 drugs may be compared at once

Generic Name and Formulations:
Evolocumab 140mg/mL; per prefilled syringe or SureClick autoinjector; soln for SC inj; preservative-free.
Company:
Amgen, Inc.

Select therapeutic use: Hyperlipoproteinemias
Indications for REPATHA:
Adjunct to diet and maximally tolerated statin therapy, in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease requiring additional lowering of LDL-C. Adjunct to diet and other LDL-lowering therapies, in patients with homozygous familial hypercholesterolemia (HoFH) requiring additional lowering of LDL-C.

Limitations Of use:
Effect on cardiovascular morbidity and mortality has not been determined.

Adult:
Give by SC inj into abdomen, thigh, or upper arm; rotate inj sites. HeFH or primary hyperlipidemia: 140mg every 2 weeks or 420mg once monthly. HoFH: (≥13yrs): 420mg once monthly; measure LDL-C levels 4–8 weeks after initiation. To administer 420mg dose: give over 9 mins by using the on-body infusor or as 3 inj consecutively within 30 mins using the prefilled syringe or autoinjector.

Children:
HeFH or primary hyperlipidemia: not established. HoFH: <13yrs: not established.

Warnings/Precautions:
Do not inject into areas that are tender, bruised, red, or indurated. Discontinue if serious allergic reactions occur. Severe renal or hepatic impairment. Pregnancy. Nursing mothers.

Interactions:
Avoid co-administration with other injectable drugs at same inj site.

See Also:
REPATHA PUSHTRONEX

Pharmacological Class:
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor.

Adverse Reactions:
Nasopharyngitis, URTI, influenza, back pain, inj site reactions.

Generic Availability:
NO

How Supplied:
Single-use prefilled syringe—1; Single-use prefilled SureClick autoinjector—1, 2, 3; Single-use Pushtronex system—1