ACTHREL Rx
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ACTHREL
Miscellaneous diagnostic tests  Only 4 drugs may be compared at once
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Generic Name and Formulations:
Corticorelin ovine (as the trifluoroacetate) 100mcg/vial; pwd for IV inj after reconstitution.
Company:
Ferring Pharmaceuticals, Inc.

Select therapeutic use: Miscellaneous diagnostic tests
Indications for ACTHREL:
For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.

Adults and Children:
Testing pituitary corticotrophin function: 1mcg/kg IV as a single dose. ACTH and cortisol response prolonged and remain elevated for up to 2 hours. Doses >1mcg/kg: not recommended. If repeat test needed, do tests at the same time of day as original test.

Warnings/Precautions:
Higher doses associated with transient tachycardia, decreased BP, loss of consciousness, and asystole; symptoms may be reduced if given as a 30 second IV infusion instead of bolus inj. Pregnancy (Cat.C). Nursing mothers.

Interactions:
Plasma ACTH response inhibited by dexamethasone. Heparin to maintain IV cannula patency: not recommended.

Pharmacological Class:
Corticotropin-releasing hormone (CRH) analogue.

Adverse Reactions:
Flushing of the face, neck, upper chest; tachycardia, hypotension, dyspnea, chest compression or tightness with higher doses.

How Supplied:
Single-dose vial—1