NAPRELAN
Dysmenorrhea 
Nonnarcotic analgesics  Only 4 drugs may be compared at once
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Generic Name and Formulations:
Naproxen (as sodium) 375mg, 500mg, 750mg; controlled rel tabs.
Company:
Alvogen
 
Select therapeutic use: Arthritis/rheumatic disorders
Dysmenorrhea
Nonnarcotic analgesics
Indications for NAPRELAN:
Rheumatoid arthritis. Osteoarthritis. Ankylosing spondylitis. Acute gout. Tendinitis. Bursitis.

Adult:
Rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis: 750mg–1g once daily; max 1.5g once daily. Acute tendonitis or bursitis: 1g once daily, or 1.5g once daily for a limited period; max 1g/day thereafter. Gout: 1–1.5g once daily for 1 day then 1g once daily until attack subsides.

Children:
Not recommended.

Contraindications:
Aspirin allergy. 3rd trimester pregnancy. Coronary artery bypass graft surgery.

Warnings/Precautions:
Advanced renal disease: not recommended. Active peptic ulcer. History of GI disease. Impaired renal or hepatic function. Heart failure. Edema. Hypertension. Pre-existing asthma. Bleeding disorders. Monitor blood, ocular, and liver function in chronic use. Discontinue if liver dysfunction occurs. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:
Avoid aspirin. Serum levels increased by probenecid. May potentiate protein-bound drugs (eg, phenytoin, sulfonylureas, sulfonamides). Monitor oral anticoagulants. May antagonize diuretics, antihypertensives. Increased renal toxicity with ACE inhibitors. Methotrexate excretion reduced. Increases lithium levels. Increased risk of GI bleed with alcohol.

Pharmacological Class:
NSAID (arylacetic acid deriv.).

Adverse Reactions:
GI upset, bleeding, or ulceration; headache, flu syndrome, constipation, abdominal pain, dizziness, paresthesias, insomnia, rash (discontinue if occurs), edema, hyperglycemia, arthralgia, myalgia, renal dysfunction, blood dyscrasias, others. See literature re: risk of cardiovascular events.

How Supplied:
Tabs 375mg—100; 500mg—75; 750mg—30; Dose card (10-day therapy)—20 (750mg x 6 tabs + 500mg x 14 tabs)
Indications for NAPRELAN:
Dysmenorrhea.

Adult:
1g once daily, or 1.5g once daily for a limited period; max 1g/day thereafter.

Children:
Not applicable.

Contraindications:
Aspirin allergy. 3rd trimester pregnancy. Coronary artery bypass graft surgery.

Warnings/Precautions:
Advanced renal disease: not recommended. Active peptic ulcer. History of GI disease. Impaired renal or hepatic function. Heart failure. Edema. Hypertension. Pre-existing asthma. Bleeding disorders. Monitor blood, ocular, and liver function in chronic use. Discontinue if liver dysfunction occurs. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:
Avoid aspirin. Serum levels increased by probenecid. May potentiate protein-bound drugs (eg, phenytoin, sulfonylureas, sulfonamides). Monitor oral anticoagulants. May antagonize diuretics, antihypertensives. Increased renal toxicity with ACE inhibitors. Methotrexate excretion reduced. Increases lithium levels. Increased risk of GI bleed with alcohol.

Pharmacological Class:
NSAID (arylacetic acid deriv.).

Adverse Reactions:
GI upset, bleeding, or ulceration; headache, flu syndrome, constipation, abdominal pain, dizziness, paresthesias, insomnia, rash (discontinue if occurs), edema, hyperglycemia, arthralgia, myalgia, renal dysfunction, blood dyscrasias, others. See literature re: risk of cardiovascular events.

How Supplied:
Tabs 375mg—100; 500mg—75; 750mg—30; Dose card (10-day therapy)—20 (750mg x 6 tabs + 500mg x 14 tabs)
Indications for NAPRELAN:
Mild to moderate pain.

Adult:
1g once daily, or 1.5g once daily for a limited period; max 1g/day thereafter.

Children:
Not recommended.

Contraindications:
Aspirin allergy. 3rd trimester pregnancy. Coronary artery bypass graft surgery.

Warnings/Precautions:
Advanced renal disease: not recommended. Active peptic ulcer. History of GI disease. Impaired renal or hepatic function. Heart failure. Edema. Hypertension. Pre-existing asthma. Bleeding disorders. Monitor blood, ocular, and liver function in chronic use. Discontinue if liver dysfunction occurs. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:
Avoid aspirin. Serum levels increased by probenecid. May potentiate protein-bound drugs (eg, phenytoin, sulfonylureas, sulfonamides). Monitor oral anticoagulants. May antagonize diuretics, antihypertensives. Increased renal toxicity with ACE inhibitors. Methotrexate excretion reduced. Increases lithium levels. Increased risk of GI bleed with alcohol.

Pharmacological Class:
NSAID (arylacetic acid deriv.).

Adverse Reactions:
GI upset, bleeding, or ulceration; headache, flu syndrome, constipation, abdominal pain, dizziness, paresthesias, insomnia, rash (discontinue if occurs), edema, hyperglycemia, arthralgia, myalgia, renal dysfunction, blood dyscrasias, others. See literature re: risk of cardiovascular events.

How Supplied:
Tabs 375mg—100; 500mg—75; 750mg—30; Dose card (10-day therapy)—20 (750mg x 6 tabs + 500mg x 14 tabs)