Generic Name and Formulations:
Moxifloxacin (as HCl) 400mg; tabs.
Company:
Bayer Healthcare Pharmaceuticals Inc.
Indications for AVELOX:
Susceptible bacterial infections including acute sinusitis, acute exacerbations of chronic bronchitis, community acquired pneumonia, skin and skin structure, complicated intra-abdominal infections, plague.

Adult:
≥18yrs: 400mg once daily. Sinusitis: treat for 10 days. Bronchitis: treat for 5 days. Pneumonia: treat for 7–14 days. Skin and skin structure: treat for 7 days, if complicated: 7–21 days. Intra-abdominal: treat for 5–14 days. Plague: treat for 10–14 days; begin as soon as possible after suspected or confirmed exposure. IV formulation may be used if oral route not preferable; administer IV infusion over 60 minutes, may switch from IV to oral route when clinically indicated.

Children:
<18yrs: not established.

Warnings/Precautions:
History of myasthenia gravis; avoid. Increased risk of tendinitis and tendon rupture esp. in patients >60yrs, or those with kidney, heart or lung transplants. CNS disorders (eg, seizures). Discontinue if tendon pain, inflammation, or rupture occurs; or if allergic reaction or CNS events occur. History of QT prolongation or proarrhythmic conditions (eg, hypokalemia, bradycardia, acute myocardial ischemia). Do not exceed recommended dose or infusion rate; may increase QT prolongation. Discontinue immediately if symptoms of peripheral neuropathy occur. Maintain adequate hydration. Monitor blood glucose in diabetic patients; discontinue if hypoglycemia occurs. Hepatic impairment. Avoid excessive sun or UV light. Elderly. Pregnancy (Cat.C), nursing mothers: not recommended.

Interactions:
Avoid drugs that prolong QTc interval (eg, Class IA or Class III antiarrhythmics, erythromycin, antipsychotics, tricyclics). Oral forms: take at least 4hrs before or 8hrs after iron, zinc, magnesium, aluminum, sucralfate, didanosine (buffered forms). Increased risk of tendinitis and tendon rupture with corticosteroids. Monitor warfarin. Concomitant antidiabetics may cause blood glucose disturbances. Concomitant NSAIDs may increase seizure risk.

See Also:
AVELOX I.V.

Pharmacological Class:
Quinolone.

Adverse Reactions:
Nausea, diarrhea, dizziness, headache, convulsions, other CNS effects, abdominal pain, inj site reaction; hypersensitivity reactions, abnormal liver function tests, rash, phototoxicity (discontinue if occurs), tendinitis/rupture, peripheral neuropathy (may be irreversible).

Generic Availability:
YES

How Supplied:
Tabs—30; ABC Pack (5 tabs)—1; Premixed IV soln (250mL)—1