Generic Name and Formulations:
Pentoxifylline 400mg; ext-rel tabs.

Company:
Sanofi Aventis
Indications for TRENTAL:
Intermittent claudication.

Adult:
400mg three times daily with meals. Continue for at least 8 weeks. Digestive or CNS effects: lower dosage to 400mg twice daily; discontinue if side effects persist. Severe renal impairment (CrCl <30mL/min): 400mg once daily.

Children:
Not established.

Contraindications:
Recent cerebral or retinal hemorrhage. Methylxanthines intolerance (eg, caffeine, theophylline, theobromine).

Warnings/Precautions:
Discontinue if anaphylactic/anaphylactoid reaction occurs. Monitor for bleeding including hematocrit, hemoglobin in patients with hemorrhagic risk factors (eg, recent surgery, peptic ulcer, cerebral and/or retinal bleeding). Renal or hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:
See Contraindications. May potentiate antihypertensives; monitor BP. Concomitant theophylline-containing drugs; monitor closely and adjust dose. Concomitant warfarin; monitor PT frequently. May be potentiated by strong CYP1A2 inhibitors (eg, ciprofloxacin, fluvoxamine).

Pharmacological Class:
Hemorrheologic agent (xanthine).

Adverse Reactions:
GI upset, nausea, dyspepsia, flushing, agitation, headache, dizziness, insomnia, blurred vision.

Metabolism:
Hepatic.

Elimination:
Renal (primarily), fecal.

Generic Availability:
YES

How Supplied:
Tabs—100