Generic Name and Formulations:
Pregabalin 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg; caps.

Company:
Pfizer Inc.
Indications for LYRICA:
Fibromyalgia.

Adult:
≥18yrs: initially 75mg twice daily, may increase to 150mg twice daily within 1 week as tolerated; max 450mg/day. Renal impairment (CrCl <60mL/min): reduce dose (see literature); hemodialysis: give supplemental dose after session.

Children:
<18yrs: not recommended.

Warnings/Precautions:
Avoid abrupt cessation (taper over ≥1 week). Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. CHF. Ocular conditions. Diabetes (monitor skin integrity). Suicidal tendencies (monitor). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:
Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones.

See Also:
LYRICA ORAL SOLUTION

Pharmacological Class:
alpha2-delta ligand.

Adverse Reactions:
Dizziness, somnolence, other CNS effects, dry mouth, edema, ocular/visual effects (eg, blurring), weight gain, thinking abnormal (primarily difficulty with concentration/attention), infection, asthenia, paresthesias, elevated creatine kinase, decreased platelets, arrhythmias (PR prolongation); male-mediated teratogenicity; may be tumorigenic.

How Supplied:
Caps—90; Soln—16oz