Generic Name and Formulations:
Pantoprazole (as sodium) 40mg; per vial; pwd for IV infusion after reconstitution and dilution; contains edetate disodium.

Company:
Pfizer Inc.
Indications for PROTONIX I.V.:
Short-term treatment (7–10 days) of GERD associated with a history of erosive esophagitis. Pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome).

Adult:
≥18yrs: GERD: 40mg once daily for 7–10 days; switch to tabs or oral suspension as soon as possible. Pathological hypersecretory conditions: 80mg every 8–12 hrs; usual max 240mg/day or 6 days' treatment.

Children:
<18yrs: not established.

Warnings/Precautions:
Gastric malignancy. Discontinue if acute interstitial nephritis occurs. Long-term therapy may lead to malabsorption/deficiency of Vit. B12 or atrophic gastritis. Increased risk of osteoporosis-related fractures (hip, wrist or spine) with long-term and multiple daily dose PPI therapy. Monitor magnesium levels with long-term therapy. Use lowest effective dose for shortest duration. Reeva luate periodically. IV: consider zinc supplementation in those prone to zinc deficiency. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:
Concomitant atazanavir or nelfinavir: not recommended. May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, iron, atazanavir, erlotinib, mycophenolate mofetil, ampicillin). Concomitant digoxin or drugs that may cause hypomagnesemia (eg, diuretics); consider monitoring magnesium levels. Monitor warfarin. May give antacids concomitantly. IV: caution with concomitant other EDTA-containing products. May potentiate methotrexate. May cause false (+) urine THC test.

See Also:
PROTONIX TABLETS

PROTONIX for ORAL SUSP

Pharmacological Class:
Proton pump inhibitor.

Adverse Reactions:
Headache, diarrhea, nausea, vomiting, flatulence, dizziness, arthralgia, inj site reactions; also children: fever, rash, abdominal pain; hypomagnesemia (w. prolonged PPI therapy), possible C. difficile-associated diarrhea.

Metabolism:
Hepatic (CYP2C19, 3A4). 98% protein bound.

Elimination:
Renal (primarily), fecal.

Generic Availability:
Tabs, IV (YES); oral soln (NO)

How Supplied:
Tabs—90; Susp—30 packets/box; Vials (40mg)—1, 10, 25