Generic Name and Formulations:
Cefoxitin sodium 1g, 2g; for IV inj; sodium content 2.3mEq/g.

Company:
Various generic manufacturers
Indications for Cefoxitin Injection:
Susceptible bacterial septicemia, lower respiratory or urinary tract, skin and skin structure, bone and joint, gynecologic, intraabdominal infections. Surgical prophylaxis.

Adult:
Usually 1–2g every 6–8hrs. Uncomplicated: 1g every 6–8hrs. Moderately severe to severe: 1g every 4hrs or 2g every 6–8hrs. Max 2g every 4hrs or 3g every 6hrs. Prophylaxis: see literature.

Children:
<3months: not recommended. ≥3months: 80–160mg/kg per day in 4–6 equal divided doses; max 12g/day. Prophylaxis: see literature.

Warnings/Precautions:
Penicillin or other allergy. Renal impairment (CrCl <50mL/min), reduce dose: see literature. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers.

Interactions:
Aminoglycosides may potentiate nephrotoxicity. Potentiated by probenecid. May cause false (+) Clinitest. May interfere with creatinine tests.

Pharmacological Class:
Cephalosporin.

Adverse Reactions:
Local reactions, rash, pruritus, drug fever, GI upset, anaphylaxis, blood dyscrasias, elevated liver enzymes.

Note:
Formerly known under the brand name Mefoxin.

How Supplied:
Contact supplier.