Generic Name and Formulations:
Eprosartan (as mesylate), hydrochlorothiazide; 600mg/12.5mg, 600mg/25mg; tabs.

Company:
AbbVie
Indications for TEVETEN HCT:
Hypertension (not for initial therapy).

Adult:
May be substituted for titrated components. ≥18yrs: One Teveten HCT 600mg/12.5mg tab once daily; after 2–3 weeks may increase to one Teveten HCT 600mg/25mg tab once daily. May add eprosartan 300mg once daily in the PM if additional BP control is needed at trough. Moderate-to-severe renal impairment: max 600mg daily.

Children:
<18yrs: not established.

Contraindications:
Anuria. Sulfonamide allergy. Concomitant aliskiren in patients with diabetes.

Warnings/Precautions:
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before starting, or monitor closely. Hepatic dysfunction. Renal impairment: monitor for worsening renal function. Renal artery stenosis. Severe CHF. Asthma. Diabetes. Postsympathectomy. SLE. Gout. Acute myopia and secondary angle-closure glaucoma. Monitor BP, electrolytes. Elderly. Neonates. Pregnancy (Cat.D); avoid. Nursing mothers: not recommended.

Interactions:
See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; avoid. Avoid concomitant aliskiren in renal impairment (CrCl <60mL/min). Hyperkalemia with K+ supplements, K+ sparing diuretics, or K+ containing salt substitutes. May be antagonized by, and renal toxicity potentiated by NSAIDs, including COX-2 inhibitors; monitor renal function periodically in elderly and/or volume-depleted. Adjust antidiabetic, antigout medications. ACTH, corticosteroids increase hypokalemia risk. Orthostatic hypotension potentiated by alcohol, CNS depressants. Reduced absorption with bile acid resins (eg, cholestyramine, colestipol). Potentiates other antihypertensives. May potentiate nondepolarizing muscle relaxants. May interfere with parathyroid tests. May antagonize norepinephrine. May increase lithium levels; monitor.

Pharmacological Class:
Angiotensin II receptor blocker + thiazide diuretic.

Adverse Reactions:
Dizziness, back pain, orthostatic hypotension, electrolyte disturbances, adverse lipid values, rhabdomyolysis (rare).

Metabolism:
Hepatic. 98% protein bound.

Elimination:
Renal, biliary.

Generic Availability:
NO

How Supplied:
Tabs—100