Generic Name and Formulations:
Minocycline (as HCl) 50mg, 75mg, 100mg; pellet-filled caps.

Company:
Onset Dermatologics
Indications for MINOCIN:
Adjunct in severe acne.

Adult:
Swallow whole. Take on empty stomach with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:
Swallow whole. Take on empty stomach with fluids.<8yrs: not recommended. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. Renal impairment (CrCl <80mL/min): max 200mg/day.

Pharmacological Class:
Tetracycline antibiotic.

Warnings/Precautions:
Discontinue if serious dermatological reaction (eg, DRESS) or superinfection occurs. Women who are overweight or have history of intracranial hypertension. eva luate if visual disturbance occurs. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Monitor blood, renal, and hepatic function periodically. Monitor skeletal development (esp. in children). Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:
Avoid penicillins, methoxyflurane, isotretinoin. Caution with other hepatotoxic drugs. Reduced absorption with antacids containing aluminum, calcium, or magnesium and iron-containing products. May reduce effectiveness of oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. Monitor PT with oral anticoagulants. May interfere with fluorescence test.

Adverse Reactions:
Dizziness, anorexia, nausea, vomiting, diarrhea, rash, pseudotumor cerebri, blood dyscrasias, increased BUN, interstitial nephritis, hepatotoxicity, tinnitus, tooth discoloration; photosensitivity, C. diff-associated diarrhea.

How Supplied:
Caps—60

Indications for MINOCIN:
Susceptible respiratory, genitourinary, skin and soft tissue, ear/nose/throat infections.

Adult:
Swallow whole. Take on empty stomach with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Syphilis: treat for 10–15 days. Meningococcal carrier state: 100mg every 12 hours for 5 days. Mycobacterium marinum infection: 100mg every 12 hours for 6–8 weeks has been used. Uncomplicated urethral, endocervical, or rectal infection w. C.trachomatis or U. urealyticum: 100mg every 12 hours for at least 7 days. For men: Uncomplicated gonococcal infection (not urethritis or anorectal): 200mg once then 100mg every 12 hours for at least 4 days; urethritis: 100mg every 12 hours for 5 days. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:
Swallow whole. Take on empty stomach with fluids.<8yrs: not recommended. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. Renal impairment (CrCl <80mL/min): max 200mg/day.

Pharmacological Class:
Tetracycline.

Warnings/Precautions:
Discontinue if serious dermatological reaction (eg, DRESS) or superinfection occurs. Women who are overweight or have history of intracranial hypertension. eva luate if visual disturbance occurs. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Monitor blood, renal, and hepatic function periodically. Monitor skeletal development (esp. in children). Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:
Avoid penicillins, methoxyflurane, isotretinoin. Caution with other hepatotoxic drugs. Reduced absorption with antacids containing aluminum, calcium, or magnesium and iron-containing products. May reduce effectiveness of oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. Monitor PT with oral anticoagulants. May interfere with fluorescence test.

Adverse Reactions:
Dizziness, anorexia, nausea, vomiting, diarrhea, rash, pseudotumor cerebri, blood dyscrasias, increased BUN, interstitial nephritis, hepatotoxicity, tinnitus, tooth discoloration; photosensitivity, C. diff-associated diarrhea.

How Supplied:
Caps—60