Generic Name and Formulations:
Dipyridamole 200mg (ext-rel), aspirin 25mg (immediate-release); caps.

Company:
Boehringer Ingelheim Pharmaceuticals
Indications for AGGRENOX:
To reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis.

Adult:
Swallow whole. 1 cap twice daily, one in the morning and one in the evening. Alternative regimen in case of intolerable headaches: switch to 1 cap at bedtime and low-dose aspirin in AM; return to usual regimen as soon as possible, usually within 1 week.

Children:
Not recommended.

Pharmacological Class:
Combination antiplatelet.

Contraindications:
NSAID allergy. Patients with the syndrome of asthma, rhinitis, and nasal polyps. Viral infection in children/teens (risk of Reye syndrome).

Warnings/Precautions:
Not interchangeable with individual components of aspirin and dipyridamole. Increased risk of bleeding, including GI bleed. History of active peptic ulcer, severe hepatic or renal dysfunction; avoid. Coronary artery disease. Pre-existing hypotension. Chronic, heavy alcohol use. Pregnancy (Cat.D); avoid during 3rd trimester and during labor & delivery. Nursing mothers.

Interactions:
Increased risk of bleeding with anticoagulants, antiplatelets, heparin, fibrinolytic therapy, alcohol, chronic NSAID use. Potentiates adenosine, acetazolamide, methotrexate, oral hypoglycemics. May antagonize ACE inhibitors, β-blockers, diuretics, cholinesterase inhibitors, uricosurics. May increase risk of renal dysfunction with NSAIDs. Monitor phenytoin, valproic acid, other anticonvulsants.

Adverse Reactions:
Headache, dyspepsia, abdominal pain, nausea, diarrhea; bleeding risk, increased liver enzymes, hepatic failure.

Metabolism:
Hepatic. 99% protein bound.

Elimination:
Fecal, renal.

Generic Availability:
YES

How Supplied:
Caps—60