Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram may improve your ability to exercise. It is not known if Orenitram is safe and effective in children under 18 years of age.
ORENITRAM Rx
Generic Name and Formulations:
Treprostinil 0.125mg, 0.25mg, 1mg, 2.5mg; ext-rel osmotic tabs.

Company:
United Therapeutics Corp.
Indications for ORENITRAM:
Pulmonary arterial hypertension (PAH) (WHO Group 1) in patients with WHO functional Class II–III symptoms, to improve exercise capacity.

Adult Dose for ORENITRAM:
Take with food. Swallow whole. Individualize. Initially 0.25mg twice daily (~12hrs apart); may increase in increments of 0.25mg or 0.5mg twice daily every 3–4 days; if not tolerated, consider titrating slower. The total daily dose can be divided and given approx. 8 hrs apart, titrating by increments of 0.125mg three times daily. If intolerable adverse effects occur, decrease in 0.25mg increments. Mild hepatic impairment (Child Pugh Class A) or concomitant strong CYP2C8 inhibitors (eg, gemfibrozil): initially 0.125mg twice daily; titrate by increments of 0.125mg twice daily every 3–4 days. Moderate hepatic impairment (Child Pugh Class B): not recommended. Treatment interruption or discontinuation: see full labeling.

Children's Dose for ORENITRAM:
Not established.

Pharmacological Class:
Prostacyclin analogue.

Contraindications:
Severe hepatic impairment (Child Pugh Class C).

Warnings/Precautions:
Avoid abrupt withdrawal or sudden large dose reduction (see full labeling). Increased risk of bleeding. Hepatic impairment. Diverticulosis or blind-end pouches. Elderly. Labor & delivery. Pregnancy (Cat. C). Nursing mothers: not recommended.

Interactions:
Avoid alcohol. Increased risk of symptomatic hypotension with concomitant diuretics, antihypertensives, or other vasodilators. Increased risk of bleeding with anticoagulants. Potentiated by CYP2C8 inhibitors (eg, gemfibrozil).

Adverse Reactions:
Headache, nausea, diarrhea, flushing, pain in extremity, jaw pain, hypokalemia, abdominal discomfort.

How Supplied:
Ext-rel tabs—100