Generic Name and Formulations:
Brinzolamide 1%, brimonidine tartrate 0.2%; oph susp; contains benzalkonium chloride.

Company:
Alcon Laboratories, Inc.
诺华旗下爱尔康公司用于治疗青光眼的固定剂量复合制剂（混悬剂）Simbrinza获FDA批准。Simbrinza能够降低原发性开角型青光眼或高眼压症患者升高的眼内压(IOP)。眼内压是青光眼唯一可以缓解的风险因素，已证实Simbrinza可以使眼内压降低21%至35%。
Simbrinza是碳酸酐酶抑制剂（1.0%布林佐胺）与α-2肾上腺素受体激动剂（0.2%酒石酸溴莫尼定）混合而成的一种多剂量瓶装药剂，患者每日滴3次，每次1滴。
在两项大约1300名患者参与的关键临床试验中，进行三个月后，本品治疗组患者的平均眼内压优于仅使用单一药物（每天3次）患者的眼内压，具有统计学意义。
爱尔康认为Simbrinza的主要亮点是可以降低患者的药物负担以及能对患者的眼内压提供持久的日常控制。
两项临床试验中，报道最频繁的不良反应是视力模糊、眼睛刺激性、味觉障碍、口干和眼睛过敏，在本品用药患者中，有11%的患者主要因报道的不良反应中止治疗。
虽然青光眼的真正病因还不清楚，但对患者来说，保持正常范围的眼内压，控制主要的风险因素显然是非常重要的。然而诊断本身也是一个问题，因为大约50%的青光眼在发生相当大的、不可逆损伤时还没得到诊断，导致一种俗称“视力偷窃者”的情形。

Indications for SIMBRINZA:
Reduction of elevated intraocular pressure in open-angle glaucoma or ocular hypertension.

Adults and Children's Dose:
<2yrs: contraindicated. ≥2yrs: 1 drop three times daily.

Pharmacological Class:
Carbonic anhydrase inhibitor + alpha-2 agonist.

Contraindications:
Neonates and infants <2yrs.

Warnings/Precautions:
Sulfonamide allergy. Discontinue if serious systemic or hypersensitivity reactions occur. Increased risk of corneal edema in patients with low endothelium cell counts. Severe renal impairment (CrCl <30mL/min): not recommended. Hepatic impairment. Severe cardiovascular disease. Depression. Cerebral or coronary insufficiency. Raynaud’s phenomenon. Orthostatic hypotension. Thromboangitis obliterans. Acute angle-closure glaucoma. Remove soft contact lenses before use; may reinsert 15mins later. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:
Concomitant oral carbonic anhydrase inhibitors: not recommended. Caution with antihypertensives, cardiac glycosides, tricyclic antidepressants, MAOIs. Concomitant high-dose salicylate may produce acid-base and electrolyte alterations. May be potentiated by CNS depressants (eg, alcohol, opiates, barbiturates, sedatives, anesthetics). Separate administration of other oph drugs by ≥5 minutes.

Adverse Reactions:
Blurred vision, eye irritation, dysgeusia, dry mouth, eye allergy.

How Supplied:
Susp—8mL