Indications for KEPPRA INJECTION:
Use when oral administration is temporarily not feasible: as adjunct in partial onset seizures; and adjunct in myoclonic seizures in patients with juvenile myoclonic epilepsy; and as adjunct in primary generalized tonic-clonic seizures in adults with idiopathic generalized epilepsy.
Adult Dose for KEPPRA INJECTION:
≥16yrs: Infuse over 15 minutes. Partial onset: Initially 500mg twice daily; may increase at 2-week intervals in increments of 1g/day; max 3g/day. Myoclonic and primary generalized tonic-clonic: Initially 500mg twice daily; increase at 2-week intervals in increments of 1g/day to target dose of 3g/day. Renal impairment: CrCl 50–80mL/min: 500mg–1g every 12 hours; CrCl 30–50mL/min: 250–750mg every 12 hours; CrCl <30mL/min: 250–500mg every 12 hours; ESRD patients on dialysis: 500mg–1g every 24 hours and a supplement of 250–500mg post-dialysis.
Children's Dose for KEPPRA INJECTION:
<16yrs: not recommended.
See Also:
KEPPRA
KEPPRA ORAL SOLUTION
KEPPRA XR
Warnings/Precautions:
Renal impairment. Monitor for psychiatric symptoms and the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes. Avoid abrupt cessation. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.C); monitor carefully esp. during 3rd trimester. Nursing mothers: not recommended.
Adverse Reactions:
Somnolence, asthenia, infection, dizziness, coordination difficulties (eg, ataxia, abnormal gait), mood and behavioral abnormalities (eg, irritability, anger, depression, anxiety, apathy), neck pain, pharyngitis, hematologic abnormalities, dermatological reactions; may be serious (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), discontinue if occurs; rare: psychotic symptoms. Children: also fatigue, nasal congestion, accidental injury, hostility, nervousness; BP increases in children 1month–4yrs. XR: also nausea.
Note:
Register pregnant patients exposed to levetiracetam by calling (888) 537-7734.
How Supplied:
Tabs 250mg, 500mg, 750mg—120; 1000mg—60; XR—60; Soln—16oz; Single-use vials (5mL)—10
Indications for KEPPRA INJECTION:
Use when oral administration is temporarily not feasible: as adjunct in partial onset seizures; and adjunct in myoclonic seizures in patients with juvenile myoclonic epilepsy; and as adjunct in primary generalized tonic-clonic seizures in adults with idiopathic generalized epilepsy.
Adult Dose for KEPPRA INJECTION:
≥16yrs: Infuse over 15 minutes. Partial onset: Initially 500mg twice daily; may increase at 2-week intervals in increments of 1g/day; max 3g/day. Myoclonic and primary generalized tonic-clonic: Initially 500mg twice daily; increase at 2-week intervals in increments of 1g/day to target dose of 3g/day. Renal impairment: CrCl 50–80mL/min: 500mg–1g every 12 hours; CrCl 30–50mL/min: 250–750mg every 12 hours; CrCl <30mL/min: 250–500mg every 12 hours; ESRD patients on dialysis: 500mg–1g every 24 hours and a supplement of 250–500mg post-dialysis.
Children's Dose for KEPPRA INJECTION:
<16yrs: not recommended.
See Also:
KEPPRA
KEPPRA ORAL SOLUTION
KEPPRA XR
Warnings/Precautions:
Renal impairment. Monitor for psychiatric symptoms and the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes. Avoid abrupt cessation. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.C); monitor carefully esp. during 3rd trimester. Nursing mothers: not recommended.
Adverse Reactions:
Somnolence, asthenia, infection, dizziness, coordination difficulties (eg, ataxia, abnormal gait), mood and behavioral abnormalities (eg, irritability, anger, depression, anxiety, apathy), neck pain, pharyngitis, hematologic abnormalities, dermatological reactions; may be serious (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), discontinue if occurs; rare: psychotic symptoms. Children: also fatigue, nasal congestion, accidental injury, hostility, nervousness; BP increases in children 1month–4yrs. XR: also nausea.
Note:
Register pregnant patients exposed to levetiracetam by calling (888) 537-7734.
How Supplied:
Tabs 250mg, 500mg, 750mg—120; 1000mg—60; XR—60; Soln—16oz; Single-use vials (5mL)—10
