Cefazolin for Injection, USP
|
Zone Diameter (mm) |
Interpretation |
|
≥18 |
Susceptible (S) |
|
15-17 |
Intermediate (I) |
|
≤14 |
Resistant (R) |
|
Microorganism |
Zone Diameter (mm) |
|
E. coli ATCC 25922 |
21-27 |
|
S. aureus ATCC 25923 |
29-35 |
|
MIC (mcg/mL) |
Interpretation |
|
≤16 |
Susceptible (S) |
|
≥64 |
Resistant (R) |
|
Microorganism |
MIC (mcg/mL) |
|
S. aureus ATCC 25923 |
0.25-1 |
|
E. coli ATCC 25922 |
1-4 |
Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.
|
Type of Infection |
Dose |
Frequency |
|
*In rare instances, doses of up to 12 grams of cefazolin per day have been used. |
|
Moderate to severe infections |
500 mg to 1 gram |
every 6 to 8 hrs. |
Mild infections caused by susceptible
gram-positive cocci |
250 mg to 500 mg |
every 8 hours |
Acute, uncomplicated urinary tract
infections |
1 gram |
every 12 hours |
|
Pneumococcal pneumonia |
500 mg |
every 12 hours |
Severe, life-threatening infections
(e.g., endocarditis, septicemia)* |
1 gram to 1.5 grams |
every 6 hours |
|
Pediatric Dosage Guide |
|
Weight |
25 mg/kg/day
Divided into 3 Doses |
25 mg/kg/day
Divided into 4 Doses |
|
Lbs |
Kg |
Approximate
Single Dose
mg/q8h |
Vol. (mL)
needed with
dilution of 125
mg/mL |
Approximate
Single Dose
mg/q6h |
Vol. (mL) needed
with dilution of
125 mg/mL |
|
10 |
4.5 |
40 mg |
0.35 mL |
30 mg |
0.25 mL |
|
20 |
9 |
75 mg |
0.6 mL |
55 mg |
0.45 mL |
|
30 |
13.6 |
115 mg |
0.9 mL |
85 mg |
0.7 mL |
|
40 |
18.1 |
150 mg |
1.2 mL |
115 mg |
0.9 mL |
|
50 |
22.7 |
190 mg |
1.5 mL |
140 mg |
1.1 mL |
Weight |
50 mg/kg/day
Divided into 3 Doses |
50 mg/kg/day
Divided into 4 Doses |
|
Lbs |
Kg |
Approximate
Single Dose
mg/q8h |
Vol. (mL)
needed with
dilution of 225
mg/mL |
Approximate
Single Dose
mg/q6h |
Vol. (mL)
needed with
dilution of
225 mg/mL |
|
10 |
4.5 |
75 mg |
0.35 mL |
55 mg |
0.25 mL |
|
20 |
9 |
150 mg |
0.7 mL |
110 mg |
0.5 mL |
|
30 |
13.6 |
225 mg |
1 mL |
170 mg |
0.75 mL |
|
40 |
18.1 |
300 mg |
1.35 mL |
225 mg |
1 mL |
|
50 |
22.7 |
375 mg |
1.7 mL |
285 mg |
1.25 mL |
|
Vial Size |
Amount of
Diluent |
Approximate
Concentration |
Approximate
Available
Volume |
|
500 mg |
2 mL |
225 mg/mL |
2.2 mL |
|
1 gram |
2.5 mL |
330 mg/mL |
3 mL |
 
Manufacturer
Aurobindo Pharma Limited
Active Ingredients
Source
-
U.S. National Library of Medicine
-
DailyMed
-
Last Updated: 2nd of March 2011
|
