Indications for VIAGRA:

Erectile dysfunction.

Adult Dose for VIAGRA:

Take 1 dose as needed about 1 hr (½–4 hrs) before sexual activity at frequency of up to once daily. Initially 50mg. May reduce dose to 25mg or increase to max of 100mg. Elderly, hepatic impairment, severe renal impairment, or concomitant potent CYP3A4 inhibitors (eg, erythromycin, ketoconazole, itraconazole, saquinavir): consider initial dose of 25mg. Concomitant ritonavir, indinavir, or atazanavir: max single sildenafil dose of 25mg in 48 hrs. Concomitant α-blockers (eg, doxazosin): do not take >25mg dose of sildenafil within 4 hours of an α-blocker.

Children's Dose for VIAGRA:

Not recommended.

Pharmacological Class:

Phosphodiesterase type 5 inhibitor (cGMP-specific).

Contraindications:

Concomitant organic nitrates or nitric oxide donors (eg, sodium nitroprusside).

Warnings/Precautions:

Confirm diagnosis. Cardiovascular disease (eg, MI, stroke, or life-threatening arrhythmia within 6 months; BP<90/50 or >170/110; unstable angina, LV outflow obstruction, impaired autonomic regulation of BP). Anatomical penile deformation. Predisposition to priapism. Patients for whom sexual activity is inadvisable or contraindicated. Bleeding disorders. Active peptic ulcer. Retinitis pigmentosa: not recommended. Pregnancy (Cat.B).

Interactions:

Hypotension with nitrates: see Contraindications. Concomitant α-blockers (eg, doxazosin) may lead to symptomatic hypotension. Plasma levels increased by inhibitors of CYP3A4 (eg, ketoconazole, itraconazole, erythromycin, saquinavir, ritonavir, lopinavir, indinavir) or CYP2C9, or cimetidine. Plasma levels reduced by inducers of CYP3A4 (eg, rifampin). Concomitant other erectile dysfunction treatments: not recommended.

Adverse Reactions:

Headache, flushing, dyspepsia, nasal congestion, UTI, diarrhea, dizziness, rash, visual disturbances (eg, color tinge to vision, increased light sensitivity, blurred vision), sudden vision or hearing loss (discontinue if occurs); rarely: cardiovascular events, prolonged erection, priapism.

How Supplied:

Tabs 25mg—30; Tabs 50mg, 100mg—30, 100