Generic Name and Formulations:
Cinacalcet 30mg, 60mg, 90mg, tabs.

Company:
Amgen, Inc.

 

Indications for SENSIPAR:

Hypercalcemia in patients with parathyroid carcinoma.

Adult Dose for SENSIPAR:

Swallow whole; take with food. Individualize. ≥18yrs: initially 30mg twice daily. May titrate dose every 2–4 weeks through sequential doses of 30mg twice daily, 60mg twice daily, 90mg twice daily, and 90mg 3–4 times daily until serum calcium normalizes.

Children's Dose for SENSIPAR:

<18yrs: not recommended.

Pharmacological Class:

Calcimimetic.

Warnings/Precautions:

Do not initiate if serum calcium <8.4mg/dL. Obtain serum calcium within 1 week after start of therapy, during dose adjustment, then every 2 months. Suspend if serum calcium <7.5mg/dL or persistent hypocalcemia symptoms occur; may restart at next lowest dose if resolved. Monitor for adynamic bone disease; if iPTH levels decrease below target range (150–300pg/mL), reduce dose or discontinue. History of seizures. Cardiovascular disorders. Moderate and severe hepatic impairment. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates CYP2D6 substrates (eg, metoprolol, carvedilol, flecainide, vinblastine, thioridazine, and TCAs). Potentiated by CYP3A4 inhibitors (eg, ketoconazole, itraconazole, erythromycin); may need to adjust dose.

Adverse Reactions:

Nausea, vomiting, hypocalcemia.

How Supplied:

Tabs—30