ACIPHEX (rabeprazole sodium) tablet, delayed release 

ACIPHEX SPRINKLE (rabeprazole sodium) granule, delayed release 

 [Eisai Inc.] 

雷贝拉唑钠缓释颗粒

 

Generic Name and Formulations:

 Rabeprazole sodium 5mg, 10mg; delayed-release, caps

 

Company:

Eisai and Janssen

 

e-Prescribe this drug via Surescripts

  

Therapeutic Use:

 

Hyperacidity, GERD, and ulcers 

 

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Drug News:

•Aciphex Sprinkle Now Available for Pediatric GERD

•Aciphex Sprinkle Approved for GERD in Children Under 11 Years

•FDA Accepts Aciphex Pediatric NDA for Priority Review

 

Gastrohepatic Disorders Resource Center » 

 

 

Indications for ACIPHEX SPRINKLE:

 

Triple therapy (w. amoxicillin + clarithromycin) for H. pylori eradication in duodenal ulcer disease. Short-term treatment of erosive or ulcerative gastroesophageal reflux disease (GERD) or duodenal ulcers. Short-term treatment of symptomatic GERD in patients ≥12 years of age. Maintenance of healing and reduction in relapse rates of heartburn symptoms in erosive or ulcerative GERD. Long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome). Treatment of GERD in pediatric patients 1–11 years of age.

 

Adult Dose for ACIPHEX SPRINKLE:

 

Swallow tabs whole. ≥18yrs: Triple therapy: rabeprazole 20mg + amoxicillin 1g + clarithromycin 500mg, all twice daily (w. AM and PM meals) for 7 days. GERD healing: 20mg once daily for 4–8 weeks; may repeat for 8 more weeks. GERD symptoms: 20mg once daily for 4 weeks; may repeat for 4 more weeks. GERD maintenance: 20mg once daily. Duodenal ulcer healing: 20mg once daily after breakfast for up to 4 weeks. Hypersecretory conditions: initially 60mg once daily; titrate; doses up to 100mg once daily or 60mg twice daily have been used.

 

Children's Dose for ACIPHEX SPRINKLE:

 

Sprinkle caps: take 30 minutes before meal. Open capsule and sprinkle contents on a small amount of soft food (eg, applesauce, fruit or vegetable based baby food, yogurt) or into a small amount of liquid (eg, infant formula, apple juice, pediatric electrolyte solution). <1yr: not recommended. Treatment of GERD: 1–11yrs (<15kg): 5mg once daily for up to 12 weeks; may increase to 10mg if inadequate response; (>15kg):10mg once daily for up to 12 weeks. Tabs: swallow whole. Treatment of symptomatic GERD: ≥12yrs: 20mg tab once daily for up to 8 weeks.

 

See Also:

 

ACIPHEX

 

Pharmacological Class:

 

Proton pump inhibitor.

 

Warnings/Precautions:

 

Gastric malignancy. Increased risk of osteoporosis-related fractures of the hip, wrist or spine with long-term and multiple daily dose PPI therapy. Severe hepatic impairment. Monitor magnesium levels with long-term therapy. Pregnancy (Cat.B). Nursing mothers: not recommended.

 

Interactions:

 

May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, digoxin). Concomitant digoxin or drugs that cause may hypomagnesemia (eg, diuretics): consider monitoring magnesium levels. May give antacids concomitantly. May antagonize atazanavir (not recommended). Monitor warfarin, cyclosporine. May potentiate methotrexate (see literature).

 

Adverse Reactions:

 

Headache, pain, pharyngitis, flatulence, infection, constipation; rare: hypomagnesemia (w. prolonged PPI therapy), possible C. difficile associated diarrhea.

 

Note:

 

Note: See Amoxil entry for more information on amoxicillin. See Biaxin entry for more information on clarithromycin.

 

How Supplied:

 

Tabs—30, 90; Caps—30