Generic Name and Formulations:
Lubiprostone 8mcg, 24mcg; caps.

Company:
Sucampo and Takeda

Indications for AMITIZA:
Irritable bowel syndrome with constipation (IBS–C) in women.

Adult Dose for AMITIZA:
Swallow whole. Take with food and water. ≥18yrs: 8mcg twice daily. Severe hepatic impairment (Child-Pugh Class C): 8mcg once daily.

Children's Dose for AMITIZA:
<18yrs: not recommended.

Pharmacological Class:
GI motility enhancer (chloride channel activator).

Contraindications:
Known or suspected mechanical GI obstruction.

Warnings/Precautions:
Confirm absence of GI obstruction before starting therapy. Severe diarrhea: not recommended. Renal or hepatic impairment. Reeva luate periodically. Pregnancy (Cat.C). Nursing mothers; monitor infants for diarrhea.

Interactions:
Possibly antagonized by diphenylheptane opioids (eg, methadone).

Adverse Reactions:
Nausea, headache, diarrhea (suspend therapy if occurs), abdominal pain, abdominal distension, flatulence, dyspnea, vomiting, syncope, asthenia, others.

Elimination:
Renal (primary), fecal.

How Supplied:
8mcg—60; 24mcg—60, 100