中文名：苯磺酸贝托司汀
英文名：Bepotastine besilate
英文化学名：(+)-(S)-4-[4-[1-(4-Chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid benzenesulfonate
分子式：C21H25ClN2O3.C6H6O3S
分子量：547.07
CAS号：190786-44-8
分子结构式：
Bepreve (bepotastine ophthalmic solution)
适应症：眼部瘙痒与过敏性结膜炎
生产商：Ista Pharmaceuticals
批准日期：2009年9月8日
Bepreve是一种非镇静性、高度选择性组胺（H1）受体拮抗剂，对肥大细胞有稳定作用和阻止其迁移人炎症组织并激活其中的嗜酸性粒细胞。
BEPREVE ® (bepotastine besilate ophthalmic solution) 1.5%, for topical ophthalmic use
Initial U.S. Approval: 2009
INDICATIONS AND USAGE
BEPREVE® (bepotastine besilate ophthalmic solution) 1.5% is a histamine H1 receptor antagonist indicated for the treatment of itching associated with allergic conjunctivitis.
IMPORTANT SAFETY INFORMATION
BEPREVE is contraindicated in patients with a history of hypersensitivity reactions to bepotastine or any of the other ingredients.
BEPREVE is for topical ophthalmic use only. To minimize risk of contamination, do not touch the dropper tip to the eyelids or to any surface. Keep the bottle closed when not in use.
BEPREVE should not be used to treat contact lens-related irritation. Remove contact lens prior to instillation of BEPREVE. Lenses may be reinserted 10 minutes after BEPREVE administration.
The most common adverse reaction occurring in approximately 25% of patients was a mild taste following instillation. Other adverse reactions occurring in 2%-5% of patients were eye irritation, headache, and nasopharyngitis.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=68bbf6a0-c4b5-47c1-8a1c-08220fbdbce6 |
