es of a low-fat breakfast include: • 2 slices of white toast with 1 tablespoon of low-fat margarine and 1 tablespoon of jelly, and 8 ounces of skim milk (319 calories and 8.2 grams fat), or • 1 cup of cereal, 8 ounces of skim milk, 1 slice of toast with jelly, apple juice, and 1 cup of coffee or tea (520 calories and 2 grams fat). • Your healthcare provider may stop your treatment or change the dose of your treatment if you get side effects. • If you miss a dose, take it as soon as you remember on that day. Do not take two doses on the same day to make up for a missed dose. • If you take too much Stivarga call your healthcare provider or go to the nearest emergency room right away.
What should I avoid while taking Stivarga?
• Avoid drinking grapefruit juice and taking St. John’s Wort while taking Stivarga. These can affect the way Stivarga works.
What are the possible side effects of Stivarga?
Stivarga can cause serious side effects including:
• See “What is the most important information I should know about Stivarga?” • severe bleeding. Stivarga can cause bleeding which can be serious and sometimes lead to death. Tell your healthcare provider if you have any signs of bleeding while taking Stivarga including: o vomiting blood or if your vomit looks like coffee-grounds o pink or brown urine o red or black (looks like tar) stools o coughing up blood or blood clots o menstrual bleeding that is heavier than normal o unusual vaginal bleeding o nose bleeds that happen often • a skin problem called hand-foot skin reaction and skin rash. Hand-foot skin reactions can cause redness, pain, blisters, bleeding, or swelling on the palms of your hands or soles of your feet. If you get this side effect or a skin rash, your healthcare provider may stop your treatment for some time. • high blood pressure. Your blood pressure should be checked every week for the first 6 weeks of starting Stivarga. Your blood pressure should be checked regularly and any high blood pressure should be treated while you are receiving Stivarga. Tell your healthcare provider if you have severe headaches, lightheadedness, or changes in your vision. • decreased blood flow to the heart and heart attack. Get emergency help right away and call your healthcare provider if you get symptoms such as chest pain, shortness of breath, feel dizzy or feel like passing out. • a condition called Reversible Posterior Leukoencephalopathy Syndrome (RPLS). Call your healthcare provider right away if you get: severe headaches, seizure, confusion, or change in vision. • a tear in your stomach or intestinal wall (perforation). Tell your healthcare provider right away if you get: • severe pain in your stomach-area (abdomen) • swelling of the abdomen • high fever • wound healing problems. If you need to have a surgical procedure, tell your healthcare provider that you are taking Stivarga. You should stop taking Stivarga at least 2 weeks before any planned surgery.
The most common side effects of Stivarga include:
• tiredness, weakness, fatigue • loss of appetite • frequent or loose bowel movements (diarrhea) • swelling, pain and redness of the lining in your mouth, throat, stomach and bowel (mucositis) • weight loss • infection • voice changes or hoarseness
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of Stivarga. For m
