acy of PEPAXTO has not been established for use as a conditioning regimen in patients receiving transplant.
Secondary malignancies such as myelodysplastic syndromes or acute leukemia have been reported in patients with multiple myeloma who were treated with PEPAXTO. Monitor patients long term for the development of secondary malignancies.
Based on its mechanism of action, PEPAXTO can cause fetal harm when administered to a pregnant woman because it is genotoxic and targets actively dividing cells. Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment with PEPAXTO and for 6 months after the last dose. Advise males with female partners of reproductive potential to use effective contraception during treatment with PEPAXTO and for 3 months after the last dose.
The most common adverse reactions (≥20%; Grade 1-4)were fatigue (55%), nausea (32%), diarrhea (27%), pyrexia(24%), and respiratory tract infection (24%).
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