n PEGASUS, BRILINTA vs aspirin alone, TIMI Total Major bleeding (1.7% vs 0.8%)and dyspnea (14% vs 6%)
DRUG INTERACTIONS
Avoid use with strong CYP3A inhibitors and strong CYP3A inducers. BRILINTA is metabolized by CYP3A4/5. Strong inhibitors substantially increase ticagrelor exposure and so increase the risk of adverse events. Strong inducers substantially reduce ticagrelor exposure and so decrease the efficacy of ticagrelor
Patients receiving more than 40 mg per day of simvastatin or lovastatin may be at increased risk of statin-related adverse events
Monitor digoxin levels with initiation of, or change in, BRILINTA therapy |
