enal crisis when thyroid hormone therapy is initiated. Patients with diabetes mellitus may require upward adjustments of their antidiabetic therapeutic regimens when treated with levothyroxine.
Adverse reactions associated with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage.
Levothyroxine should not be discontinued during pregnancy and hypothyroidism diagnosed during pregnancy should be promptly treated.
Drug Interactions: Many drugs affect thyroid hormone pharmacokinetics and metabolism, and thyroid hormones and thyroid status have varied effects on the pharmacokinetics and actions of other drugs. Levothyroxine increases the response to oral anticoagulant therapy and may reduce the therapeutic effects of digitalis glycosides. Prescribers should consult appropriate reference sources for drug-thyroidal axis interactions.
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