Elvitegravir (ritonavir-boosted)
Ritonavir
Saquinavir (unboosted)a
Monitor for adverse reactions. See also Table 5.
Concomitant Drug Within Class Prevention or Management
Tenofovir disoproxil fumarate Monitor for adverse reactions.
Beta Blockers
Nadolola Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Calcium Channel Blockers
Felodipinea
Nisoldipine
Contraindicated during and 2 weeks after TOLSURA
treatment.
Diltiazem
Other dihydropyridines
Verapamil
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary. For diltiazem, see also
Table .
Cardiovascular Drugs, Miscellaneous
Ivabradine
Ranolazine
Contraindicated during and 2 weeks after TOLSURA
treatment.
Aliskirena
Riociguat
Sildenafil (for pulmonary hypertension)
Tadalafil (for pulmonary hypertension)
Not recommended during and 2 weeks after TOLSURA
treatment. For sildenafil and tadalafil, see also Urologic
Drugs below.
Bosentan
Guanfacine
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Contraceptives
Dienogest
Ulipristal
Monitor for adverse reactions.
Diuretics
Eplerenone Contraindicated during and 2 weeks after TOLSURA
treatment.
Gastrointestinal Drugs
Naloxegol Contraindicated during and 2 weeks after TOLSURA
treatment.
Aprepitant
Loperamidea
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Netupitant Monitor for adverse reactions.
Immunosuppressants
Everolimus
Sirolimus
Temsirolimus (IV)
Not recommended during and 2 weeks after TOLSURA
treatment.
Concomitant Drug Within Class Prevention or Management
Budesonide (inhalation)a
Budesonide
(noninhalation)
Ciclesonide (inhalation)
Cyclosporine (IV)a
Cyclosporine (non-IV)
Dexamethasonea
Fluticasone (inhalation)a
Fluticasone (nasal)
Methylprednisolonea
Tacrolimus (IV)a
Tacrolimus (oral)
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Lipid-Lowering Drugs
Lomitapide
Lovastatina
Simvastatina
Contraindicated during and 2 weeks after TOLSURA
treatment.
Atorvastatina Monitor for drug adverse reactions. Concomitant drug
dose reduction may be necessary.
Respiratory Drugs
Salmeterol Not recommended during and 2 weeks after TOLSURA
treatment.
SSRIs, Tricyclics and Related Antidepressants
Venlafaxine Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Urologic Drugs
Avanafil Contraindicated during and 2 weeks after TOLSURA
treatment.
Fesoterodine Patients with moderate to severe renal or hepatic
impairment: Contraindicated during and 2 weeks after
TOLSURA treatment.
Other patients: Monitor for adverse reactions.
Concomitant drug dose reduction may be necessary
Solifenacin Patients with severe renal or moderate to severe hepatic
impairment: Contraindicated during and 2 weeks after
TOLSURA treatment.
Other patients: Monitor for adverse reactions.
Concomitant drug dose reduction may be necessary.
Darifenacin
Vardenafil
Not recommended during and 2 weeks after TOLSURA
treatment.
Dutasteride
Oxybutynina
Sildenafil (for erectile dysfuncti |
