r adverse reactions. Concomitant drug dose
reduction may be necessary.
Antibacterials
Bedaquilineb Concomitant TOLSURA not recommended for more
than 2 weeks at any time during bedaquiline treatment.
Concomitant Drug Within Class Prevention or Management
Rifabutin Not recommended 2 weeks before, during, and 2 weeks
after TOLSURA treatment. See also Table 5.
Clarithromycin Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary. See also Table 5.
Trimetrexate Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Anticoagulants and Antiplatelets
Ticagrelor Contraindicated during and 2 weeks after TOLSURA
treatment.
Apixaban
Rivaroxaban
Vorapaxar
Not recommended during and 2 weeks after TOLSURA
treatment.
Cilostazol
Dabigatran
Warfarin
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Anticonvulsants
Carbamazepine Not recommended 2 weeks before, during, and 2 weeks
after TOLSURA treatment. See also Table 5.
Antidiabetic Drugs
Repaglinidea
Saxagliptin
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Antihelminthics, Antifungals and Antiprotozoals
Isavuconazonium Contraindicated during and 2 weeks after TOLSURA
treatment.
Praziquantel Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Artemether-lumefantrine
Quininea
Monitor for adverse reactions.
Antimigraine Drugs
Ergot alkaloids (e.g., dihydroergotamine, ergotamine) Contraindicated during and 2 weeks after TOLSURA
treatment.
Eletriptan Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary
Antineoplastics
Irinotecan Contraindicated during and 2 weeks after TOLSURA
treatment.
Concomitant Drug Within Class Prevention or Management
Axitinib
Bosutinib
Cabazitaxel
Cabozantinib
Ceritinib
Cobimetiniba
Crizotinib
Dabrafenib
Dasatinib
Docetaxel
Ibrutinib
Lapatinib
Nilotinib
Olapariba
Pazopanib
Sunitinib
Trabectedin
Trastuzumab-emtansine
Vinca alkaloids
Not recommended during and 2 weeks after TOLSURA
treatment.
Bortezomib
Brentuximab-vedotin
Busulfana
Erlotinib
Gefitiniba
Idelalisib
Imatinib
Ixabepilone
Nintedanib
Panobinostat
Ponatinib
Ruxolitinib
Sonidegib
Vandetaniba
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary. For Idelalisib, see also
Table 5.
Antipsychotics, Anxiolytics and Hypnotics
Alprazolama
Aripiprazolea
Buspironea
Diazepama
Haloperidola
Midazolam (IV)a
Quetiapine
Ramelteon
Risperidonea
Suvorexant
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Zopiclonea Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary.
Lurasidone
Midazolam (oral)a
Pimozide
Triazolama
Contraindicated during and 2 weeks after TOLSURA
treatment.
Antivirals
Simeprevir Not recommended during and 2 weeks after TOLSURA
treatment.
Daclatasvir
Indinavira
Maraviroc
Monitor for adverse reactions. Concomitant drug dose
reduction may be necessary. For indinavir, see also Table
5.
Cobicistat
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