nd seizures during treatment with LORBRENA. In some patients, these problems are severe and your healthcare provider may need to have you stop taking LORBRENA.
Increases in the cholesterol and triglycerides (lipid) levels in your blood. Most patients will have an increase in the lipid levels in your blood during treatment with LORBRENA.
If you have increases in the lipid levels in your blood during treatment with LORBRENA, your healthcare provider may need to start you on a medicine to lower the levels. If you are already taking a medicine to lower the lipid levels in your blood, your healthcare provider may need to increase your dose of that medicine.
Your healthcare provider should do blood tests to check the lipid levels in your blood before starting treatment, 1 to 2 months after starting treatment, and during treatment with LORBRENA.
Heart problems. LORBRENA may cause very slow or abnormal heartbeats. Your healthcare provider should check your heart rhythm (electrocardiogram [EKG]) before starting and during treatment with LORBRENA. Tell your healthcare provider right away if you feel dizzy or faint or have abnormal heartbeats. In some patients, these problems are severe and your healthcare provider may need to have you stop taking LORBRENA or have a pacemaker placed.
Lung problems. LORBRENA may cause severe or life-threatening swelling (inflammation) of the lungs during treatment that can lead to death. Symptoms may be similar to those from lung cancer. Tell your healthcare provider right away if you have any new or worsening symptoms of lung problems, including trouble breathing, shortness of breath, cough, or fever.
In some patients, these problems are severe and your healthcare provider may need to have you stop taking LORBRENA. See "What are possible side effects of LORBRENA?" for more information about side effects.
What is LORBRENA?
LORBRENA is a prescription medicine that is used to treat people with non-small cell lung cancer (NSCLC)
that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene and,
that has spread to other parts of your body and,
who have taken the medicine alectinib or ceritinib or who have taken both the medicine crizotinib and at least 1 other medicine to treat NSCLC that is caused by the ALK gene, and
their NSCLC is no longer responding to these treatments.
It is not known if LORBRENA is safe and effective in children.
Do not take LORBRENA if you take certain other medicines called strong CYP3A inducers. Ask your healthcare provider for a list of these medicines if you are not sure.
Before taking LORBRENA, tell your healthcare provider about all of your medical conditions, including if you:
are taking other medications
have had episodes of depression or seizures
have high levels of cholesterol or triglycerides in your blood
have problems with your heart beat
have lung or breathing problems
are pregnant or plan to become pregnant. LORBRENA can harm your unborn baby.
Your healthcare provider will do a pregnancy test before you start treatment with LORBRENA.
Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with LORBRENA.
–
Females who are able to become pregnant should use effective non-hormonal birth control during treatment with LORBRENA and for at least 6 months after the final dose of LORBRENA. Birth control pills (oral contraceptives) and other hormonal forms of birth control may not be effective if used during treatment with LORBREN |
