lysis, meningitis
Endocrine Disorders: hyperthyroidism
Gastrointestinal System Disorders: duodenal ulcer, esophagitis, gingivitis, gastroenteritis, GI hemorrhage, hematemesis, hemorrhoids, intestinal obstruction, intestinal perforation, melena, paralytic ileus, peptic ulcer, pseudomembranous colitis, colitis, pancreatitis, peritonitis, hyperbilirubinemia, hepatic failure, hepatocellular damage, hypoalbuminemia, biliary pain
Hearing and Vestibular Disorders: decreased hearing
Metabolic and Nutritional Disorders: acidosis, aggravated diabetes mellitus, dehydration, fluid overload, hyperglycemia, hyperkalemia, hypokalemia, hypoglycemia, hyponatremia, increased alkaline phosphatase, respiratory alkalosis
Musculoskeletal System Disorders: arthritis or worsening arthritis, arthropathy, bone fracture, myositis, muscle atrophy, muscle weakness, osteomyelitis, polymyositis
Neoplasms: malignant lymphoma, malignant testicular neoplasm, prostatic cancer, plasma cell dyscrasia, secondary leukemia, squamous cell carcinoma, transformation to aggressive lymphoma, transformation to prolymphocytic leukemia
Platelet, Bleeding, and Clotting Disorders: coagulation disorder, disseminated intravascular coagulation, hematoma, pulmonary embolism, thrombocythemia
Psychiatric Disorders: confusion, hallucinations, nervousness, abnormal thinking, apathy
White Cell and RES Disorders: agranulocytosis, aplasia, decreased haptoglobin, lymphadenopathy, marrow depression
Red Blood Cell Disorders: hemolysis, hemolytic anemia, splenic infarction, splenomegaly
Reproductive System Disorders: cervical dysplasia
Resistance Mechanism Disorders: abscess, bacterial infection, Herpes zoster infection, Pneumocystis carinii infection, otitis media, Tuberculosis infection, viral infection
Respiratory System Disorders: asthma, bronchitis, chronic obstructive pulmonary disease, hemoptysis, hypoxia, pleural effusion, pleurisy, pneumothorax, pulmonary edema, pulmonary fibrosis, pulmonary infiltration, respiratory depression, respiratory insufficiency, sinusitis, stridor, throat tightness
Skin and Appendages Disorders: angioedema, bullous eruption, cellulitis, purpuric rash
Special Senses Disorders: taste loss
Urinary System Disorders: abnormal renal function, acute renal failure, anuria, facial edema, hematuria, toxic nephropathy, ureteric obstruction, urinary retention, urinary tract infection
Vascular (Extracardiac) Disorders: cerebral hemorrhage, cerebrovascular disorder, deep vein thrombosis, increased capillary fragility, intracranial hemorrhage, phlebitis, subarachnoid hemorrhage, thrombophlebitis
Vision Disorders: endophthalmitis
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OVERDOSAGE
Initial doses of Campath of greater than 3 mg are not well-tolerated. One patient who received 80 mg as an initial dose by IV infusion experienced acute bronchospasm, cough, and shortness of breath, followed by anuria and death. A review of the case suggested that tumor lysis syndrome may have played a role.
Single doses of Campath greater than 30 mg or a cumulative weekly dose greater than 90 mg should not be administered as higher doses have been associated with a higher incidence of pancytopenia. (See BOXED WARNING and DOSAGE AND ADMINISTRATION.)
There is no known specific antidote for Campath overdosage. Treatment cons |
