ually given on Day 1, Day 3, and Day 5 of a 28-day treatment cycle.
This is 1 treatment cycle. You may receive up to 6 treatment cycles.
Your healthcare provider will give you medicines and IV fluids before and after yourinfusions.
It is important for you to drink the additional prescribed amount of fluids (water, milk, orjuice) of up to twelve 8-oz glasses every 24 hours on Days 1 through 8 of each 28-daytreatment cycle when you receive LUMOXITI infusions.
Your healthcare provider will decide how many treatment cycles you need.
If you miss any appointments, call your healthcare provider as soon as possible toreschedule your appointment.
What are the possible side effects of LUMOXITI?
LUMOXITI can cause serious side effects, including:
See “What is the most important information I should know about LUMOXITI?”
Kidney problems. LUMOXITI may cause kidney problems. People who have HUS, are 65 years of age or older, or those who have kidney problems before starting treatment
with LUMOXITI may have an increased risk of worse kidney problems after treatment
with LUMOXITI. Tell your healthcare provider right away if you have any changes in theamount you urinate. Your healthcare provider will do tests to check your kidneys before you receive each dose of LUMOXITI and as needed during treatment.
Your healthcare
provider may delay your treatment with LUMOXITI if you have severe kidney problems.
Infusion reactions. LUMOXITI can cause infusion reactions that are common but canalso be serious. Infusion reactions may happen on the day you receive your LUMOXITI
infusion. Signs and symptoms of infusion reactions may include:
o chills o headache
o cough o changes in blood pressure
o dizziness o muscle pain
o shortness of breath or wheezing o nausea
o feeling hot or flushing o fever
o fast heartbeat o vomiting
Your healthcare provider may give you medicines to take before and after each
LUMOXITI infusion.
Electrolyte problems. Tell your healthcare provider if you get any of the following symptoms of electrolyte problems:
o muscle cramps o nausea
o numbness or tingling o seizures
o abnormal or fast heartbeat
Your healthcare provider will do blood tests to check your electrolytes before youreceive each dose of LUMOXITI and during treatment as recommended by your
healthcare provider.
The most common side effects of LUMOXITI include:
swelling in your face, arms, or legs
nausea
feeling tired
headache
fever
constipation
low red blood cells (anemia)
diarrhea
These are not all the possible side effects of LUMOXITI.
Call your doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.
General information about the safe and effective use of LUMOXITI.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide.
You can ask your pharmacist or healthcare provider for information about LUMOXITI
that is written for health professionals.
What are the ingredients in LUMOXITI?
Active ingredient: moxetumomab pasudotox-tdfk
Inactive ingredients: glycine, polysorbate 80, sodium phosphate monobasic monohydrate,sucrose, and sodium hydroxide Inactive ingredients of IV Solution Stabilizer: citric acid monohydrate, polysorbate 80,sodium citrate dihydrate, Water for Injection, USP LUMOXITI is a trademark of the AstraZeneca group of companies. ©AstraZeneca 2018
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