o eye pain, swelling, or redness

Lung or breathing problems. MEKTOVI can cause lung or breathing problems. Tell your healthcare provider ifyou have any new or worsening symptoms of lung or breathing problems, including:

o shortness of breatho cough

Liver problems. Your healthcare provider should perform blood tests to check your liver function before and duringtreatment with MEKTOVI. Tell your healthcare provider if you have any of the following signs and symptoms of aliver problem:

o yellowing of your skin or the white part of your eyes (jaundice)

o dark or brown (tea-colored) urine

o nausea or vomiting

o loss of appetite

Muscle problems (rhabdomyolysis). MEKTOVI can cause muscle problems that can be severe. Treatment withMEKTOVI may increase the level of an enzyme in your blood called creatine phosphokinase (CPK) and can be asign of muscle damage. Your healthcare provider should perform a blood test to check your levels of CPK before

and during treatment. Tell your healthcare provider right away if you develop any of these symptoms:

o weakness

o muscle aches or pain

o dark, reddish urine

Bleeding problems. MEKTOVI, when taken with encorafenib, can cause serious bleeding problems, including inyour brain or stomach, that can lead to death. Call your healthcare provider and get medical help right away if you

have any signs of bleeding, including:

o headaches, dizziness, or feeling weak

o cough up blood or blood clots

o vomit blood or your vomit looks like “coffee grounds”

o red or black stool that look like tarThe most common side effects of MEKTOVI when taken with encorafenib, include:

fatigue

nausea

diarrhea

vomiting

abdominal pain

These are not all the possible side effects of MEKTOVI.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to Array BioPharma Inc. at 1-844-792-7729.

How should I store MEKTOVI?

Store MEKTOVI at room temperature between 68°F to 77°F (20°C to 25°C).

Keep MEKTOVI and all medicines out of the reach of children. 

General information about the safe and effective use of MEKTOVI.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use MEKTOVI for a condition for which it was not prescribed. Do not give MEKTOVI to other people, even if they have the

same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for informationabout MEKTOVI that is written for health professionals.

What are the ingredients in MEKTOVI?

Active ingredient: binimetinib

Inactive ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate(vegetable source), and colloidal silicon dioxide Tablet coating: polyvinyl alcohol, polyethylene glycol, titanium dioxide, talc, ferric oxide yellow, ferrosoferric oxide

Distributed by: Array BioPharma Inc. Boulder, Colorado 80301.

MEKTOVI® is a registered trademark of Array BioPharma Inc. in the United States and various other countries.

For more information, go to www.BRAFTOVIMEKTOVI.com or call 1-844-792-7729.

©2018 Array BioPharma Inc. All rights reserved.