 have lung or breathing problems

 have liver or kidney problems

 have any muscle problems

 have bleeding problems

 have high blood pressure (hypertension)

 are pregnant or plan to become pregnant. MEKTOVI can harm your unborn baby.o Females who are able to become pregnant should use effective birth control (contraception) during treatment

with MEKTOVI and for at least 30 days after the final dose of MEKTOVI.

o Talk to your healthcare provider about birth control methods that may be right for you during this time.

o Your healthcare provider will do a pregnancy test before you start taking MEKTOVI. Tell your healthcareprovider right away if you become pregnant or think you might be pregnant during treatment with MEKTOVI.

 are breastfeeding or plan to breastfeed. It is not known if MEKTOVI passes into your breast milk. Do not breastfeedduring treatment with MEKTOVI and for 3 days after the final dose of MEKTOVI. Talk to your healthcare provider

about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-countermedicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get anew medicine.

How should I take MEKTOVI?

Take MEKTOVI exactly as your healthcare provider tells you to take it. Do not change your dose or stop takingMEKTOVI unless your healthcare provider tells you to.

Your healthcare provider may change your dose of MEKTOVI, temporarily stop, or completely stop your treatmentwith MEKTOVI if you develop certain side effects.Take MEKTOVI in combination with encorafenib by mouth 2 times a day, about 12 hours apart.

MEKTOVI may be taken with or without food.

If you miss a dose of MEKTOVI, take it as soon as you remember. If it is within 6 hours of your next scheduleddose, take your next dose at your regular time. Do not make up for the missed dose.

Do not take an extra dose if you vomit after taking your scheduled dose. Take your next dose at your regular time.

If you stop treatment with encorafenib, talk to your healthcare provider about whether your MEKTOVI treatmentmay need to be stopped.

What are the possible side effects of MEKTOVI?

MEKTOVI may cause serious side effects, including:

Heart problems, including heart failure. Your healthcare provider should check your heart function before andduring treatment with MEKTOVI. Call your healthcare provider right away if you have any of the following signs and

symptoms of a heart problem: 

feeling like your heart is pounding or racing

o shortness of breath

o swelling of your ankles and feet

o feeling lightheaded

Blood clots. MEKTOVI can cause blood clots in your arms or legs, which can travel to your lungs and can lead to

death. Get medical help right away if you have the following symptoms:

o chest pain

o sudden shortness of breath or trouble breathing

o pain in your legs with or without swelling

o swelling in your arms and legs

o a cool pale arm or leg

Eye problems. MEKTOVI can cause serious eye problems that might lead to blindness. Call your healthcareprovider right away if you develop any of these symptoms of eye problems:

o blurred vision, loss of vision, or other vision changes

o see colored dots