◾infection, abscess

◾reduced number of white blood cells, swollen lymph glands

◾decrease of sugar in the blood

◾depression, anxiety

◾headache, dizziness, sleeplessness, migraine, numbness or tingling feeling(paresthesia)

◾conjunctivitis, abnormal vision

◾ear pain

◾irregular, rapid beating or pulsation of the heart(palpitation)

◾redness and/or facial flushing due to widening of blood vessels, increased blood pressure

◾runny nose, cough, hoarseness due to infection of the upper respiratory tract, sinusitis, cough increased, shortness of breath

◾diarrhoea, constipation, nausea, vomiting, abdominal pain

◾rises in the blood levels of liver enzymes (will show up in blood tests)

◾skin disorder, rash

◾muscle stiffness (hypertonia), painful muscles (myalgia), muscular debility (myasthenia), back pain, pain in extremities such as fingers and toes

◾holding urine (urine retention), protein in the urine (will show up in urine tests), urinary frequency, urinary incontinence, urinary urgency

◾painful periods (menstruation), menstrual disorder, heavy uterine bleeding especially between menstrual periods, impotence

◾injection site reaction (including redness, swelling, discoloration, inflammation, pain, allergic reaction (hypersensitivity), see ?Take special care with Extavia?), skin breakdown and tissue destruction (necrosis) at injection site (see ?Take special care with Extavia?), flu-like symptoms, fever, pain, chest pain, accumulation of fluid in arm, leg or face, lack/loss of strength, chills, sweating, malaise

List 2 Side effects reports on the marketed product from spontaneous reporting

Very common side effects means 1 or more in every 10 patients are likely to get these flu-like symptoms, chills, fever, injection site reaction, injection site inflammation, injection site pain. frequencies based on clinical trials

Common side effects means between 1 and 10 in every 100 patients are likely to get these skin breakdown and tissue destruction necrosis at injection site frequencies based on clinical trials

Uncommon side effects means between 1 and 10 in every 1,000 patients are likely to get these the number of white cells and red cells in the blood may fall, the number of platelets which help the blood to clot may fall, depression, increase in blood pressure, nausea, vomiting, change in the results of liver tests increase in the blood levels of enzymes produced by the liver, swollen and usually itching patches of skin or mucous membranes urticaria, rash, itching pruritus, loss of scalp hair, painful muscles, muscle stiffness.