2. Take off the cap from the vial and clean the rubber stopper with an alcohol wipe.

3. Unwrap the needle suitable for reconstitution and fix it to the syringe from which you removed the tip cap before.

4. Transfer the solvent from the syringe to the vial by pushing the plunger in all the way.

5. Turn the syringe-vial-assembly over, then withdraw plunger to redraw the solution.

6. Disconnect syringe and needle, leave the needle in the vial and discard both.

7. Unwrap the 30-gauge needle and connect it to the syringe.

8. Remove needle cap just before injection - you are now ready to inject.

NOTE: The injection should be administered immediately after mixing (if the injection is delayed, refrigerate the solution and inject it within 3 hours). Do not freeze.

PART II ROTATING INJECTION SITES

You need to choose a new site for each injection to allow the area time to recover and help prevent infection. Advice on which areas to choose is given in the first part of this Annex. It is a good idea to know where you plan to inject before you prepare your syringe. The schedule shown in the diagram below will help you to vary the sites appropriately. For example, give the first injection into the right side of the abdomen, choose the left side for the second injection, then move to the right thigh for the third, and so on through the diagram until all suitable areas of the body have been used. Keep a record of where and when you last gave yourself an injection. One way to do that is to note the injection site on the enclosed medication record card.

By following this schedule, you will come back to your first area (e.g. the right side of the abdomen) after 8 injections (16 days). This is called a Rotation Cycle. On our example schedule each area is split again into 6 injection sites (which adds up to 48 injection sites altogether), left, right, upper, middle and lower part of each area. If you come back to an area after one Rotation Cycle choose the most distant injection site within this area. If an area becomes sore, talk to your doctor or nurse about choosing other injection sites.

Rotation Schedule

To help you rotate the injection sites appropriately we recommend that you keep a record of the date and location of your injection. You can use the following rotation schedule.

Work through each rotation cycle in turn. Each cycle will be 8 injections (16 days), given in area 1 through to area 8 in turn. By following this sequence, you will give each area a chance to recover before receiving another injection.

Rotation Cycle 1 Rotation Cycle 2 Rotation Cycle 3 Rotation Cycle 4 Rotation Cycle 5 Rotation Cycle 6 Upper left section of each area Lower right section of each area Middle left section of each area Upper right section of each area Lower left section of each area Middle right section of each area

PART III: EXTAVIAMedication record

Instructions for keeping track of your injection sites and dates

◾Start with your first injection (or your last injection if you are not a new Extavia user).

◾Select an injection site. If you have already been using Extavia start with the area that has not been used during the last rotation cycle, i.e. the past 16 days).

◾After your injection, fill in the used injection site and date in the table in your injection record (See the example: Keeping track of your injection sites and dates).

ROTATION SCHEDULE: