eHypogammaglobulinemia includes blood immunoglobulin G decreased, immunoglobulins decreased and hypogammaglobulinemia. 

fHeadache includes headache and migraine. 

gEncephalopathy includes encephalopathy, cognitive disorder, confusional state, disturbance in attention, lethargy, mental status changes, somnolence, memory impairment, metabolic encephalopathy and thinking abnormal. 

hDizziness includes dizziness, presyncope, and syncope. 

iAcute kidney injury includes acute kidney injury and blood creatinine increased. 

jCough includes cough, productive cough, and upper-airway cough syndrome. 

kDyspnea includes dyspnea, dyspnea exertional, respiratory distress, and respiratory failure. 

lHypotension includes hypotension and orthostatic hypotension. 

Adverse Reaction All Grades 

(%) Grades 3 or Higher 

(%) 

Blood and lymphatic system disorders   

     Febrile Neutropenia 17 17 

Cardiac disorders   

     aTachycardia 13 3 

Gastrointestinal disorders   

    Diarrhea 31 1 

    Nausea 27 1 

    Constipation 16 1 

General disorders and administration site conditions   

    Pyrexia 34 6 

    bFatigue 26 7 

    cEdema 23 2 

    dPain 15 3 

    Chills 13 0 

Immune system disorders   

    Cytokine release syndrome 74 23 

    eHypogammaglobulinemia 14 4 

Infections and infestations   

    Infections-pathogen unspecified 42 25 

Investigations   

    Weight decreased 11 3 

Metabolism and nutrition disorders   

    Decreased appetite 12 4 

Musculoskeletal and connective tissue disorders   

    Arthralgia 10 0 

Nervous system disorders   

    fHeadache 21 0 

    gEncephalopathy 16 11 

    hDizziness 11 1 

Renal and Urinary Disorders   

    iAcute kidney injury 17 6 

Respiratory, thoracic and mediastinal disorders   

    jCough 19 0 

    kDyspnea 18 6 

Vascular disorders   

    lHypotension 26 8 

aArrhythmia includes atrial fibrillation, supraventricular tachycardia, ventricular extrasystoles. 

bAbdominal pain includes abdominal pain and abdominal pain upper. 

cPeripheral Neuropathy includes paraethesia,hypoaesthesia, hyperaesthesia,peripheral sensory neuropathy, and neuropathy peripheral. 

dMotor dysfunction includes muscle spasms, muscle twitching, myoclonus and myopathy. 

eSpeech disorder includes speech disorder, aphasia. 

fSeizure includes PTs seizure and status epilepticus. 

gDelirium includes delirium, agitation, and irritability. 

hSleep disorders includes sleep disorder, insomnia and nightmare.