nRash includes rash, rash maculo-papular, rash papular, and rash pruritic. 

Adverse Reaction All Grades 

(%) Grades 3 or Higher 

(%) 

Blood and lymphatic system disorders   

     Febrile Neutropenia 37 37 

Cardiac disorders   

    aTachycardia 26 4 

Gastrointestinal disorders   

    Nausea 26 3 

    Diarrhea 26 1 

    Vomiting 26 1 

    Constipation 18 0 

    bAbdominal pain 16 3 

General disorders and administration site conditions   

    Pyrexia 40 15 

    cFatigue 25 0 

    dEdema 21 1 

    Chills 10 0 

    ePain 18 3 

Immune system disorders   

    Cytokine release syndrome 79 49 

    fHypogammaglobulinemia 43 7 

Infections and infestations   

    Infections-pathogen unspecified 41 16 

    Viral infectious disorders 26 18 

    Bacterial infectious disorders 19 13 

    Fungal infectious disorders 13 7 

Investigations   

    International normalized ratio increased 13 0 

Metabolism and nutrition disorders   

    Decreased appetite 37 15 

    Fluid overload 10 7 

Musculoskeletal and connective tissue disorders   

    Myalgia 15 0 

    Arthralgia 12 1 

    Back pain 10 3 

Nervous system disorders   

    gHeadache 37 3 

    hEncephalopathy 34 10 

Psychiatric disorders   

    iDelirium 21 4 

    Anxiety 13 3 

    jSleep disorders 10 0 

Renal and urinary disorders   

    kAcute kidney injury 24 15 

Respiratory, thoracic and mediastinal disorders   

    Hypoxia 24 18 

    lCough 21 0 

    mDyspnea 16 12 

    Pulmonary edema 16 10 

    Tachypnea 12 6 

    Pleural effusion 10 4 

    Nasal congestion 10 0 

Skin and subcutaneous tissue disorders   

    nRash 16 1 

Vascular disorders   

    Hypotension 31 22 

    Hypertension 19 6 

aSpeech disorder includes aphasia and dysarthria. 

bMotor dysfunction includes muscle spasms. 

Additional important adverse reactions that did not meet the threshold criteria for inclusion in Table 2 were: 

Blood and lymphatic system disorders: disseminated intravascular coagulation (9%), histiocytosis lymphocytic hemophagocytosis (7%), coagulopathy (6%), Grade 3 and Grade 4 hypofibrinogenemia with Grade 3 and 4 CRS (16%)  

Cardiac Disorders: cardiac arrest (4%), cardiac failure (7%)