Amputations mainly involve removal of the toe. 

 You may be at a higher risk of lower limb amputation if you: have a history of amputation

have had blocked or narrowed blood vessels, usually in your leg

have damage to the nerves (neuropathy) in your leg

have had diabetic foot ulcers or sores

 

Call your doctor right away if you have new pain or tenderness, any sores, ulcers, or infections in your leg or foot. Your doctor may decide to stop your SEGLUROMET for a while if you have any of these signs or symptoms. Talk to your doctor about proper foot care. low blood sugar (hypoglycemia). If you take SEGLUROMET with another medicine that can cause low blood sugar such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered while you take SEGLUROMET. Signs and symptoms of low blood sugar may include:

 

 headache

drowsiness

hunger

irritability

 dizziness

confusion

sweating

feeling jittery or shaky

 weakness

fast heartbeat

 

vaginal yeast infection. Women who take SEGLUROMET may get vaginal yeast infections. Symptoms of a vaginal yeast infection include: vaginal odor

white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese)

vaginal itching

 

yeast infection of the penis (balanitis or balanoposthitis). Men who take SEGLUROMET may get a yeast infection of the skin around the penis. Certain men who are not circumcised may have swelling of the penis that makes it difficult to pull back the skin around the tip of your penis. Other symptoms of yeast infection of the penis include:

 

 redness, itching, or swelling of the penis

foul smelling discharge from the penis

 rash of the penis

pain in the skin around your penis

 

Talk to your doctor about what to do if you get symptoms of a yeast infection of the vagina or penis. Your doctor may suggest you use an over-the-counter antifungal medicine. Talk to your doctor right away if you use an over-the-counter antifungal medicine and your symptoms do not go away. low vitamin B12 (vitamin B12 deficiency). Using metformin for long periods of time may cause a decrease in the amount of vitamin B12 in your blood, especially if you have had low vitamin B12 blood levels before. Your doctor may do blood tests to check your vitamin B12 levels.

increased fats in your blood (bad cholesterol or LDL). 

The most common side effects of ertugliflozin include: vaginal yeast infections and yeast infections of the penis (See "What is the most important information I should know about SEGLUROMET?") 

changes in urination, including urgent need to urinate more often, in larger amounts, or at night

The most common side effects of metformin hydrochloride include: 

diarrhea

nausea

 vomiting

gas

stomach discomfort

 indigestion

weakness

headache

 

These are not all the possible side effects of SEGLUROMET.

 Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 

How should I store SEGLUROMET? Store SEGLUROMET at room temperature between 68°F to 77°F (20°C to 25°C).