Talk to your doctor about how to prevent, recognize, and manage low blood sugar (hypoglycemia), high blood sugar (hyperglycemia), complications of diabetes.

Your doctor will do blood tests to check how well your kidneys are working before and during your treatment with SEGLUROMET. 

When your body is under some types of stress, such as fever, trauma (such as a car accident), infection, or surgery, the amount of diabetes medicine you need may change. Tell your doctor right away if you have any of these conditions and follow your doctor's instructions.

When taking SEGLUROMET, you may have sugar in your urine, which will show up on a urine test.

If you take too much SEGLUROMET, call your doctor or go to the nearest hospital emergency room right away.

 

What should I avoid while taking SEGLUROMET? Avoid drinking alcohol very often, or drinking a lot of alcohol in a short period of time ("binge" drinking). It can increase your chances of getting serious side effects. 

 

What are the possible side effects of SEGLUROMET?

 SEGLUROMET may cause serious side effects, including: 

 See "What is the most important information I should know about SEGLUROMET?" dehydration. SEGLUROMET can cause some people to become dehydrated (the loss of body water and salt). Dehydration may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). 

You may be at risk of dehydration if you: have low blood pressure

take medicines to lower your blood pressure, including water pills (diuretics)

have kidney problems

are on a low sodium (salt) diet

are 65 years of age or older

Talk to your doctor about what you can do to prevent dehydration including how much fluid you should drink on a daily basis. ketoacidosis (increased ketones in your blood or urine). Ketoacidosis has happened in people who have type 1 diabetes or type 2 diabetes during treatment with SEGLUROMET. Ketoacidosis is a serious condition, which may need to be treated in a hospital. Ketoacidosis may lead to death. Ketoacidosis can happen even if your blood sugar is less than 250 mg/dL. Stop taking SEGLUROMET and call your doctor right away if you get any of the following symptoms: 

 

 nausea

vomiting

stomach-area (abdominal) pain

 tiredness

trouble breathing

 

If you get any of these symptoms during treatment with SEGLUROMET, if possible check for ketones in your urine, even if your blood sugar is less than 250 mg/dL. kidney problems. Sudden kidney injury has happened to people treated with SEGLUROMET. Talk to your doctor right away if you: reduce the amount of food or liquid you drink, for example, if you are sick or cannot eat or

you start to lose liquids from your body, for example, from vomiting, diarrhea, or being in the sun too long

 

serious urinary tract infections. Serious urinary tract infections that may lead to hospitalization have happened in people who are taking SEGLUROMET. Tell your doctor if you have any signs or symptoms of a urinary tract infection such as a burning feeling when passing urine, a need to urinate often, the need to urinate right away, pain in the lower part of your stomach (pelvis), or blood in the urine. Sometimes people may also have a fever, back pain, nausea, or vomiting.