Your doctor may tell you to take STEGLUJAN along with other diabetes medicines. Low blood sugar can happen more often when STEGLUJAN is taken with certain other diabetes medicines. See "What are the possible side effects of STEGLUJAN?".

Stay on your prescribed diet and exercise program while taking STEGLUJAN.

Check your blood sugar as your doctor tells you to.

Your doctor will check your diabetes with regular blood tests, including your blood sugar levels and your HbA1c.

Talk to your doctor about how to prevent, recognize and manage low blood sugar (hypoglycemia), high blood sugar (hyperglycemia), complications of diabetes.

Your doctor will do blood tests to check how well your kidneys are working before and during your treatment with STEGLUJAN.

When your body is under some types of stress, such as fever, trauma (such as a car accident), infection, or surgery, the amount of diabetes medicine you need may change. Tell your doctor right away if you have any of these conditions and follow your doctor's instructions.

When taking STEGLUJAN, you may have sugar in your urine, which will show up on a urine test.

If you take too much STEGLUJAN, call your doctor or go to the nearest hospital emergency room right away.

What are the possible side effects of STEGLUJAN? 

STEGLUJAN may cause serious side effects, including: 

See "What is the most important information I should know about STEGLUJAN?" 

ketoacidosis (increased ketones in your blood or urine). Ketoacidosis has happened in people who have type 1 diabetes or type 2 diabetes during treatment with STEGLUJAN. Ketoacidosis is a serious condition, which may need to be treated in a hospital. Ketoacidosis may lead to death. Ketoacidosis can happen even if your blood sugar is less than 250 mg/dL. Stop taking STEGLUJAN and call your doctor right away if you get any of the following symptoms: 

nausea

vomiting

stomach area (abdominal) pain

tiredness

trouble breathing

If you get any of these symptoms during treatment with STEGLUJAN, if possible check for ketones in your urine, even if your blood sugar is less than 250 mg/dL. 

kidney problems (sometimes requiring dialysis). Sudden kidney injury has happened to people treated with STEGLUJAN. Talk to your doctor right away if you:

reduce the amount of food or liquid you drink, for example, if you are sick or cannot eat or

you start to lose liquids from your body, for example, from vomiting, diarrhea or being in the sun too long

serious urinary tract infections. Serious urinary tract infections that may lead to hospitalization have happened in people who are taking STEGLUJAN. Tell your doctor if you have any signs or symptoms of a urinary tract infection such as a burning feeling when passing urine, a need to urinate often, the need to urinate right away, pain in the lower part of your stomach (pelvis), or blood in the urine. Sometimes people may also have a fever, back pain, nausea, or vomiting.

amputations. STEGLUJAN may increase your risk of lower limb amputations. Amputations mainly involve removal of the toe.

You may be at a higher risk of lower limb amputation if you: 

have a history of amputation

have had blocked or narrowed blood vessels, usually in your leg