grapefruit juice while taking CABOMETYX. [see DOSAGE AND ADMINISTRATION (2.1)]
Manufactured for Exelixis, Inc. South San Francisco, CA 94080
PATIENT PACKAGE INSERT
PATIENT INFORMATION
CABOMETYX® (Ka-boe-met-iks)
cabozantinib
tablets
What is CABOMETYX?
CABOMETYX is a prescription medicine used to treat people with advanced kidney cancer (renal cell carcinoma) whose cancer has spread or grown after treatment with other cancer medications.
It is not known if CABOMETYX is safe and effective in children.
Before you take CABOMETYX, tell your healthcare provider about all of your medical conditions, including if you:
have any unusual bleeding
have high blood pressure
plan to have any surgery, including dental surgery. You should stop treatment with CABOMETYX at least 28 days before any scheduled surgery.
have liver problems
are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby. If you are able to become pregnant, you should use effective birth control during treatment and for 4 months after your final dose of CABOMETYX. Talk to your healthcare provider about birth control methods that may be right for you. If you become pregnant or think you are pregnant, tell your healthcare provider right away.
are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX.
Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other causing side effects.
How should I take CABOMETYX?
Take CABOMETYX exactly as your healthcare provider tells you to take it.
Do not take CABOMETYX with food. Do not eat for at least 2 hours before and at least 1 hour after taking CABOMETYX.
Swallow CABOMETYX tablets whole with a full glass (at least 8 ounces) of water.
Do not crush CABOMETYX tablets.
If you miss a dose and your next dose is in:
ο less than 12 hours, take your next dose at the normal time. Do not make up the missed dose.
ο 12 hours or more, take the missed dose as soon as you remember. Take your next dose at the normal time.
What should I avoid while taking CABOMETYX?
Do not drink grapefruit juice, eat grapefruit or supplements that contain grapefruit during treatment with CABOMETYX.
What are the possible side effects of CABOMETYX?
CABOMETYX may cause serious side effects, including:
severe bleeding (hemorrhage). Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:
ο coughing up blood or blood clots
ο vomiting blood or if your vomit looks like coffee-grounds
ο red or black (looks like tar) stools
ο menstrual bleeding that is heavier than normal
ο any unusual or heavy bleeding
a tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach-area (abdomen).
blood clots, stroke, heart attack, and chest pain. Get emergency help right away if yo |
