e 400/120
once daily 12 1.72
(1.45, 2.04) 1.48
(1.40, 1.57) --
Ethinyl
estradiol (EE) EE/
Norgestimate
35 µg/250 µg
once daily 300/120
once daily 11 1.31
(1.24, 1.38) 1.28
(1.23, 1.32) 1.38
(1.25, 1.52)
Norgestrel 1.54
(1.34, 1.76) 1.63
(1.50, 1.76) 1.75
(1.62, 1.89)
Norgestromin ↔ 1.44
(1.34, 1.54) 1.45
(1.33, 1.58)
Ethinyl
estradiol EE/
Levonorgestrel
20 µg/100 µg
once daily 300/120
once daily 12 1.30
(1.18, 1.44) 1.40
(1.33, 1.48) 1.56
(1.41, 1.72)
Norgestrel 1.37
(1.23, 1.52) 1.68
(1.57, 1.80) 1.77
(1.58, 1.98)
Elvitegravir EVG/COBI/FTC/
TAF 150/
150/200/10
once daily 300/120
once daily 12 1.36
(1.24, 1.49) 1.47
(1.37, 1.57) 1.71
(1.50, 1.95)
Tenofovir ↔ ↔ ↔
Felodipine 2.5 single dose 300/120
once daily 11 1.31
(1.05, 1.62) 1.31
(1.08, 1.58) --
Losartan 50 single dose 300/120
once daily 12 2.51
(2.00, 3.15) 1.56
(1.28, 1.89) --
Losartan
carboxylic
acid 2.18
(1.88, 2.53) ↔ --
Lovastatin Lovastatin
10 once daily 300/120
once daily 12 ↔ 1.70
(1.40, 2.06) --
Lovastatin
acid 5.73
(4.65, 7.07) 4.10
(3.45, 4.87) --
Midazolam 1 single dose 300/120
once daily 12 ↔ 1.27
(1.11, 1.45) --
Omeprazole 20 single dose 300/120
once daily 12 0.57
(0.43, 0.75) 0.79
(0.70, 0.90) --
Pravastatin 10 once
daily 400/120
once daily 12 2.23
(1.87, 2.65) 2.30
(1.91, 2.76) --
Raltegravir 400 twice
daily 300/120
once daily 12 1.34
(0.89, 1.98) 1.47
(1.15, 1.87) 2.64
(1.42, 4.91)
Rilpivirine 25 once daily 300/120
once daily 12 2.05
(1.73, 2.43) 1.84
(1.72, 1.98) 1.77
(1.59, 1.96)
Rosuvastatin 5 once daily 400/120
once daily 11 5.62
(4.80, 6.59) 2.15
(1.88, 2.46) --
Simvastatin Simvastatin
5 once daily 300/120
once daily 12 1.99
(1.60, 2.48) 2.32
(1.93, 2.79) --
Simvastatin
acid 10.7
(7.88, 14.6) 4.48
(3.11, 6.46) --
Sofosbuvir Sofosbuvir
400 once
daily 400/120
once daily 8 1.66
(1.23, 1.22) 2.25
(1.86, 2.72) --
GS-331007 ↔ ↔ 1.85
(1.67, 2.04)
Tacrolimus 1 single
dose 300/120
once daily 10 1.50
(1.24, 1.82) 1.45
(1.24, 1.70) --
Tenofovir EFV/FTC/TDF
300/200/300
once daily 300/120
once daily 12 ↔ 1.29
(1.23, 1.35) 1.38
(1.31, 1.46)
Valsartan 80 single dose 300/120
once daily 12 1.36
(1.17, 1.58) 1.31
(1.16, 1.49) --
↔ = No change (central value ratio 0.80 to 1.25)
3TC – lamivudine; ABC – abacavir; COBI – cobicistat; DRV – darunavir; D |
