ts including transient increases in blood creatinine level and acute renal failure have occurred in some patients who take ZURAMPIC. Advise patients that periodic monitoring of blood creatinine levels are recommended [see WARNINGS AND PRECAUTIONS (5.1)].
Gout Flares
Inform patients that gout flares may occur after initiation of ZURAMPIC and of the importance of taking gout flare prophylaxis medication to help prevent gout flares. Advise patients not to discontinue ZURAMPIC if a gout flare occurs during treatment [see DOSAGE AND ADMINISTRATION (2.3)].
Manufactured for: AstraZeneca Pharmaceuticals LP, Wilmington, DE 19850
By: AstraZeneca AB, S-151 85 Södertälje, Sweden
ZURAMPIC is a trademark of the AstraZeneca group of companies.
© AstraZeneca 2015
MEDICATION GUIDE
MEDICATION GUIDE
ZURAMPIC (zer-AM-pik)
(lesinurad)
tablets
What is the most important information I should know about ZURAMPIC?
Some patients taking ZURAMPIC may have kidney problems such as a sudden decrease in kidney function (acute kidney failure). This is more common when you take ZURAMPIC without a xanthine oxidase inhibitor. You should always take ZURAMPIC with a xanthine oxidase inhibitor.
What is ZURAMPIC?
•ZURAMPIC is a prescription medicine used together with a xanthine oxidase inhibitor to lower uric acid levels in the blood in adult patients with gout.
•ZURAMPIC should not be taken without a xanthine oxidase inhibitor such as allopurinol or febuxostat.
•ZURAMPIC helps the kidneys remove uric acid from the body and is added to a xanthine oxidase inhibitor, which decreases the amount of uric acid your body makes.
•It is not known if ZURAMPIC is safe and effective in children under 18 years of age.
Who should not take ZURAMPIC?
Do not take ZURAMPIC if you have:
•severe kidney problems, received a kidney transplant or you are on dialysis
•a fast breakdown of cancer cells that can lead to high uric acid (Tumor lysis syndrome)
•a rare inherited condition that causes too much uric acid in the blood (Lesch Nyhan syndrome)
Before taking ZURAMPIC, tell your healthcare provider about all of your medical conditions, including if you:
•are pregnant or plan to become pregnant. It is not known if ZURAMPIC will harm your unborn baby.
•are breastfeeding or plan to breastfeed. It is not known if ZURAMPIC passes into your breast milk. You and your healthcare provider should decide if you should take ZURAMPIC while breastfeeding.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
ZURAMPIC may affect the way other medicines work, and other medicines may affect how ZURAMPIC works.
Especially tell your healthcare provider if you take:
•medicine for heart problems or high blood pressure
•medicine for high blood cholesterol
•antifungals and antibiotics
•valproic acid
•aspirin
•other medicines for gout
•hormonal contraceptives. Women who use birth control medicines containing hormones to prevent pregnancy (birth control pills, skin patches, implants, and certain IUDs) should use a back-up method of birth control during treatment with ZURAMPIC.
Ask your healthcare provider or pharmacist if you are not sure if you take any of these medicines.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist w |
