.8) 14 (2.6)
Pain in extremity f 79 (14.8) 66 (12.2) 61 (11.3) 8 (1.5) 8 (1.5) 7 (1.3)
Musculoskeletal pain f 67 (12.6) 59 (10.9) 36 (6.7) <1% <1% <1%
Musculoskeletal chest pain f 60 (11.3) 51 (9.4) 39 (7.2) 6 (1.1) <1% <1%
Muscular weakness f 43 (8.1) 35 (6.5) 29 (5.4) <1% 8 (1.5) <1%
Neck pain f 40 (7.5) 19 (3.5) 10 (1.8) <1% <1% <1%
Infections and infestations
Bronchitis c 90 (16.9) 59 (10.9) 43 (7.9) 9 (1.7) 6 (1.1) 3 (0.6)
Nasopharyngitis f 80 (15.0) 54 (10.0) 33 (6.1) 0 (0.0) 0 (0.0) 0 (0.0)
Urinary tract infection f 76 (14.3) 63 (11.7) 41 (7.6) 8 (1.5) 8 (1.5) <1%
Upper respiratory tract infection c % f 69 (13.0) 53 (9.8) 31 (5.7) <1% 8 (1.5) <1%
Pneumonia c @ 93 (17.5) 87 (16.1) 56 (10.4) 60 (11.3) 57 (10.5) 41 (7.6)
Respiratory tract infection % 35 (6.6) 25 (4.6) 21 (3.9) 7 (1.3) 4 (0.7) 1 (0.2)
Influenza f 33 (6.2) 23 (4.3) 15 (2.8) <1% <1% 0 (0.0)
Gastroenteritis f 32 (6.0) 17 (3.1) 13 (2.4) 0 (0.0) <1% <1%
Lower respiratory tract infection 29 (5.5) 14 (2.6) 16 (3.0) 10 (1.9) 3 (0.6) 3 (0.6)
Rhinitis f 29 (5.5) 24 (4.4) 14 (2.6) 0 (0.0) 0 (0.0) 0 (0.0)
Cellulitisc <5% <5% <5% 8 (1.5) 3 (0.6) 2 (0.4)
Sepsis c @ 33 (6.2) 26 (4.8) 18 (3.3) 26 (4.9) 20 (3.7) 13 (2.4)
Nervous system disorders
Headache f 75 (14.1) 52 (9.6) 56 (10.4) <1% <1% <1%
Dysgeusia f 39 (7.3) 45 (8.3) 22 (4.1) <1% 0 (0.0) <1%
Blood and lymphatic system disordersd
Anemia 233 (43.8) 193 (35.7) 229 (42.3) 97 (18.2) 85 (15.7) 102 (18.9)
Neutropenia 186 (35.0) 178 (33.0) 328 (60.6) 148 (27.8) 143 (26.5) 243 (44.9)
Thrombocytopenia 104 (19.5) 100 (18.5) 135 (25.0) 44 (8.3) 43 (8.0) 60 (11.1)
Febrile neutropenia 7 (1.3) 17 (3.1) 15 (2.8) 6 (1.1) 16 (3.0) 14 (2.6)
Pancytopenia 5 (0.9) 6 (1.1) 7 (1.3) 1 (0.2) 3 (0.6) 5 (0.9)
Respiratory, thoracic and mediastinal disorders
Cough f 121 (22.7) 94 (17.4) 68 (12.6) <1% <1% <1%
Dyspneac,e 117 (22.0) 89 (16.5) 113 (20.9) 30 (5.6) 22 (4.1) 18 (3.3)
Epistaxis f 32 (6.0) 31 (5.7) 17 (3.1) <1% <1% 0 (0.0)
Oropharyngeal pain f 30 (5.6) 22 (4.1) 14 (2.6) 0 (0.0) 0 (0.0) 0 (0.0)
Dyspnea exertional e 27 (5.1) 29 (5.4) <5% 6 (1.1) 2 (0.4) 0 (0.0)
Metabolism and nutrition disorders
Decreased appetite 123 (23.1) 115 (21.3) 72 (13.3) 14 (2.6) 7 (1.3) 5 (0.9)
Hypokalemia % 91 (17.1) 62 (11.5) 38 (7.0) 35 (6.6) 20 (3.7) 11 (2.0)
Hyperglycemia 62 (11.7) 52 (9.6) 19 (3.5) 28 (5.3) 23 (4.3) 9 (1.7)
Hypocalcemia 57 (10.7) 56 (10.4) 31 (5.7) 23 (4.3) 19 (3.5) 8 (1.5)
Dehydration % 25 (4.7) 29 (5.4) 17 (3.1) 8 (1.5) 13 (2.4) 9 (1.7)
Gout e <5% <5% <5% 8 (1.5) 0 (0.0) 0 (0.0)
Diabetes mellitus % e <5% <5% <5% 8 (1.5) 4 (0.7) 2 (0.4)
Hypophosphatemia e <5% <5% <5% 7 (1.3) 3 (0.6) 1 (0.2)
Hyponatremia % e <5% <5% <5% 7 (1.3) 13 (2.4) 6 (1.1)
Skin and subcutaneous tissue disorders
Rash 139 (26.1) 151 (28.0) 105 (19.4) 39 (7.3) 38 (7.0) 33 (6.1)
Pruritus f 47 (8.8) 49 (9.1) 24 (4.4) <1% <1% <1%
Psychiatric disorders
Insomnia 147 (27.6) 127 (23.5) 53 (9.8) 4 (0.8) 6 (1.1) 0 (0.0)
Depression 58 (10.9) 46 (8.5) 30 (5.5) 10 (1.9) 4 (0.7) 1 (0.2)
Vascular disorders
Deep vein thrombosisc% 55 (10.3) 39 (7.2) 22 (4.1) 30 (5.6) 20 (3.7) 15 (2.8)
Hypotensionc% 51 (9.6) 35 (6.5) 36 (6 |
