You should report any unusual or unexplained bleeding to your healthcare professional if you are taking APTIVUS together with NORVIR® (ritonavir).

What is APTIVUS?

APTIVUS is a medicine called a "protease inhibitor" that is used to treat adults with Human Immunodeficiency Virus (HIV). APTIVUS blocks HIV protease, an enzyme which is needed for HIV to make more virus. When used with other anti-HIV medicines, APTIVUS may reduce the amount of HIV in your blood and increase the number of CD4+ cells. Reducing the amount of HIV in the blood may keep your immune system healthy, so it can help fight infections.

APTIVUS is always taken with NORVIR® (ritonavir) and at the same time as NORVIR. When you take APTIVUS with NORVIR, you must always use at least 2 other anti-HIV medicines.

Does APTIVUS cure HIV or AIDS?

APTIVUS does not cure HIV infection or AIDS. The long-term effects of APTIVUS are not known at this time. People taking APTIVUS may still get infections or other conditions common in people with HIV (opportunistic infections). It is very important that you stay under the care of your doctor during treatment with APTIVUS.

Does APTIVUS lower the chance of passing HIV to other people?

APTIVUS does not reduce the chance of passing HIV to others through sexual contact, sharing needles, or being exposed to your blood. Continue to practice safer sex. Use a latex or polyurethane condom or other barrier method to lower the chance of sexual contact with any body fluids such as semen, vaginal secretions or blood. Never use or share dirty needles.

Ask your healthcare professional if you have any questions about safer sex or how to prevent passing HIV to other people.

Who should not take APTIVUS?

Do not take APTIVUS if you:

• are allergic to tipranavir or any of the other ingredients in APTIVUS. See the end of this leaflet for a list of major ingredients.
• are allergic to NORVIR® (ritonavir)
• have moderate to severe liver problems
• take any of the following types of medicines because you could have serious side effects:
  • Migraine headache medicines called "ergot alkaloids". If you take migraine headache medicines, ask your healthcare professional or pharmacist if any of them are "ergot alkaloids".
  • Halcion® (triazolam)
  • Orap® (pimozide)
  • Propulsid® (cisapride)
  • Versed® (midazolam) taken orally
  • Pacenone® (amiodarone)
  • Vascor® (bepridil)
  • Tambocor® (flecainide)
  • Rythmol® (propafenone)
  • Quinaglute dura® (quinidine)
  • Zocor® (simvastatin)
  • Mevacor® (lovastatin)
  • Uroxatral® (alfuzosin)
  • Revatio® (sildenafil) for treatment of pulmonary arterial hypertenstion


• take St. John’s wort or Rifampin. It may result in reduced virologic activity and possible resistance to tipranavir or to the class of protease inhibitors.

What should I tell my healthcare professional before I take APTIVUS?

Tell your healthcare professional about all of your medical conditions, including if you: