|
r; |
0.96 (0.89, 1.03)
0.86 (0.78, 0.94)
0.71 (0.62, 0.81) |
0.95 (0.89, 1.02)
0.96 (0.90, 1.03)
0.82 (0.66, 1.00) |
-
-
- |
|
Methadone |
5 mg
(1 dose) |
500/200 mg BID
(16 doses) |
14 |
↓ |
0.45 (0.41, 0.49) |
0.47 (0.44, 0.51) |
0.50 (0.46, 0.54) |
|
R-methadone |
|
|
|
|
0.54 (0.50, 0.58) |
0.52 (0.49, 0.56) |
- |
|
|
|
S-methadone |
|
|
|
|
0.38 (0.35, 0.43) |
0.37 (0.34, 0.41) |
- |
|
Nevirapinea |
200 mg BID
(43 doses) |
250/200 mg BID
750/100 mg BID
1250/100 mg BID
(42 doses) |
26
22
17 |
↔
↔
↔ |
0.97 (0.90, 1.04)
0.86 (0.76, 0.97)
0.71 (0.62, 0.82) |
0.97 (0.91, 1.04)
0.89 (0.78, 1.01)
0.76 (0.63, 0.91) |
0.96 (0.87, 1.05)
0.93 (0.80, 1.08)
0.77 (0.64, 0.92) |
|
Norethindrone |
1.0 mg
(1 dose) |
500/100 mg BID
750/200 mg BID
(21 doses) |
21
13 |
↔
↔ |
1.03 (0.94, 1.13)
1.08 (0.97, 1.20) |
1.14 (1.06, 1.22)
1.27 (1.13, 1.43) |
-
- |
|
Rifabutin |
150 mg
(1 dose) |
500/200 mg BID
(15 doses) |
20 |
↑ |
1.70 (1.49, 1.94) |
2.90 (2.59, 3.26) |
2.14 (1.90, 2.41) |
|
25-O-desacetyl-rifabutin |
|
|
20 |
↑ |
3.20 (2.78, 3.68) |
20.71 (17.66, 24.28) |
7.83 (6.70, 9.14) |
Rifabutin + 25-O-
desacetyl-rifabutind |
|
|
20 |
↑ |
1.86 (1.63, 2.12) |
4.33 (3.86, 4.86) |
2.76 (2.44, 3.12) |
|
Rosuvastatin |
10 mg
(1 dose) |
500/200 mg BID
(24 doses) |
16 |
↑ |
2.23 (1.83, 2.72) |
1.26 (1.08, 1.46) |
1.06 (0.93, 1.20) |
|
Saquinavir/ritonavira |
600/100 mg BID
(27 doses) |
500/200 mg BID
(28 doses) |
20
68 |
↓
↓ |
0.30 (0.23, 0.40)e
- |
0.24 (0.19, 0.32)e
- |
0.18 (0.13, 0.26)e
0.20 (0.16, 0.25)f |
|
Stavudinea |
40 mg BID ≥60 kg
30 mg BID <60 kg
(43 doses) |
250/200 mg BID
750/100 mg BID
1250/100 mg BID
(42 doses) |
26
22
19 |
↔
↔
↔ |
0.90 (0.81, 1.02)
0.76 (0.66, 0.89)
0.74 (0.69, 0.80) |
1.00 (0.91, 1.11)
0.84 (0.74, 0.96)
0.93 (0.83, 1.05) |
-
-
- |
|
Tadalafil |
10 mg
(1 dose) |
500/200 mg
(1 dose) |
17 |
& |
